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Reviews on structure and function of nitric oxide synthases

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Reviews

  1. Aiello, S., Noris, M. and Remuzzi, G. (1997) Nitric oxide synthesis and L­arginine in uremia. Miner. Electrolyte Metab. 23, 151-156.
  2. Akaike, T., Suga, M. and Maeda, H. (1998) Free radicals in viral pathogenesis: Molecular mechanisms involving superoxide and NO. Proc. Soc. Exp. Biol. Med. 217, 64-73.
  3. Alberti, C., Frattini, A. and Ferretti, S. (1993) Ruolo dell'ossido di azoto nel meccanismo erettivo. [Role of nitric oxide in the erectile mechanism] Minerva Urol. Nefrol. 45, 49-54.
  4. Albina, J.E. (1995) On the expression of nitric oxide synthase by human macrophages. Why no NO? J. Leukoc. Biol. 58, 643-649.
  5. Albina, J.E. and Reichner, J.S. (1995) Nitric oxide in inflammation and immunity. New Horiz. 3, 46-64.
  6. Alexander, B. (1998) The role of nitric oxide in hepatic metabolism. Nutrition 14, 376-390.
  7. Alexander, J., Scharton­Kersten, T.M., Yap, G., Roberts, C.W., Liew, F.Y. and Sher, A. (1997) Mechanisms of innate resistance to Toxoplasma gondii infection. Philos. Trans. R. Soc. Lond. B 352, 1355-1359.
  8. Alican, I. and Kubes, P. (1996) A critical role for nitric oxide in intestinal barrier function and dysfunction. Am. J. Physiol. 270, G225-G237.
  9. Andersson, K.E. and Persson, K. (1994) Nitric oxide synthase and nitric oxide­mediated effects in lower urinary tract smooth muscles. World J. Urol. 12, 274-280.
  10. Andersson, K.E. and Persson, K. (1995) Nitric oxide synthase and the lower urinary tract: Possible implications for physiology and pathophysiology. Scand. J. Urol. Nephrol. Suppl. 175, 43-53.
  11. Appleton, I., Tomlinson, A. and Willoughby, D.A. (1996) Induction of cyclo­oxygenase and nitric oxide synthase in inflammation. Adv. Pharmacol. 35, 27-78.
  12. Arnal, J.­F., Michel, J.­B. and Harrison, D.G. (1995) Nitric oxide in the pathogenesis of hypertension. Curr. Opin. Nephrol. Hypertens. 4, 182-188.
  13. Babu, B.R. and Griffith, O.W. (1998) Design of isoform­selective inhibitors of nitric oxide synthase. Curr. Opin. Chem. Biol. 2, 491-500.
  14. Bachmann, S. and Mundel, P. (1994) Nitric oxide in the kidney: synthesis, localization, and function. Am. J. Kidney Dis. 24, 112-129.
  15. Balligand, J.L. and Cannon, P.J. (1997) Nitric oxide synthases and cardiac muscle. Autocrine and paracrine influences. Arterioscler. Thromb. Vasc. Biol. 17, 1846-1858.
  16. Barnes, P.J. (1995a) Nitric oxide and airway disease. Ann. Med. 27, 389-393.
  17. Barnes, P.J. (1995b) Nitric oxide and asthma. Res. Immunol. 146, 698-702.
  18. Barnes, P.J. (1996) NO or no NO in asthma? Thorax 51, 218-220.
  19. Barnes, P.J. and Adcock, I. (1993) Anti­inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol. Sci. 14, 436-441.
  20. Barnes, P.J. and Liew, F.Y. (1995) Nitric oxide and asthmatic inflammation. Immunol. Today 16, 128-130.
  21. Bartsch, H., Ohshima, H., Pignatelli, B. and Calmels, S. (1992) Endogenously formed N­nitroso compounds and nitrosating agents in human cancer etiology. Pharmacogenetics 2, 272-277.
  22. Bassenge, E. (1994) Coronary vasomotor responses: role of endothelium and nitrovasodilators. Cardiovasc. Drugs Ther. 8, 601-610.
  23. Bastian, N.R. and Hibbs, J.B., Jr. (1994) Assembly and regulation of NADPH oxidase and nitric oxide synthase. Curr. Opin. Immunol. 6, 131-139.
  24. Baylis, C. and Vallance, P. (1996) Nitric oxide and blood pressure: effects of nitric oxide deficiency. Curr. Opin. Nephrol. Hypertens. 5, 80-88.
  25. Becker, Y. (1993a) Dendritic cell activity against primary tumors: An overview. In Vivo 7, 187-191.
  26. Becker, Y. (1993b) Success and failure of dendritic cell (DC) anticancer activity may be modulated by nitric oxide synthetase (NOS) gene expression: A hypothesis. In Vivo 7, 285-288.
  27. Beesley, J.E. (1995) Histochemical methods for detecting nitric oxide synthase. Histochem. J. 27, 757-769.
  28. Berkels, R., Stockklauser, K., Rosen, P. and Rosen, R. (1997) Current status of platelet NO synthases. Thromb. Res. 87, 51-55.
  29. Bevan, J.A. (1993) Flow regulation of vascular tone. Its sensitivity to changes in sodium and calcium. Hypertension 22, 273-281.
  30. Bicker, G. (1998) NO news from insect brains. Trends Neurosci. 21, 349-355.
  31. Billiar, T.R. (1995) Nitric oxide. Novel biology with clinical relevance. Ann. Surg. 221, 339-349.
  32. Billiar, T.R. and Harbrecht, B.G. (1997) Resolving the nitric oxide paradox in acute tissue damage. Gastroenterology 113, 1405-1407.
  33. Billiar, T.R., Langrehr, J.M., Curran, R.D., Ochoa, J.B., Stadler, J., Harbrecht, B.G., Hoffman, R.A. and Simmons, R.L. (1991) Two unique aspects of inducible ·N=O synthase in liver cells and accessory cells: Hepatic damage is minimized by hepatocyte ·N=O production and immunoregulation is mediated by macrophage ·N=O production. Res. Immunol. 142, 584-586.
  34. Bing, R.J. and Suzuki, H. (1996) Myocardial infarction and nitric oxide. Mol. Cell. Biochem. 160-161, 303-306.
  35. Blackwell, J.M., Barton, C.H., White, J.K., Roach, T.I., Shaw, M.A., Whitehead, S.H., Mock, B.A., Searle, S., Williams, H. and Baker, A.M. (1994) Genetic regulation of leishmanial and mycobacterial infections: The Lsh/Ity/Bcg gene story continues. Immunol. Lett. 43, 99-107.
  36. Blantz, R.C. (1994) Vascular biology: relevance of nitric oxide in vascular and nonvascular tissue with normal and decreased renal function. Blood Purif. 12, 30-35.
  37. Blottner, D., Grozdanovic, Z. and Gossrau, R. (1995) Histochemistry of nitric oxide synthase in the nervous system. Histochem. J. 27, 785-811.
  38. Bogdan, C. (1997) Of microbes, macrophages and nitric oxide. Behring Inst. Mitt. 99, 58-72.
  39. Bohle, D.S. (1998) Pathophysiological chemistry of nitric oxide and its oxygenation by­products. Curr. Opin. Chem. Biol. 2, 194-200.
  40. Booke, M., Meyer, J., Lingnau, W., Hinder, F., Traber, L.D. and Traber, D.L. (1995) Use of nitric oxide synthase inhibitors in animal models of sepsis. New Horiz. 3, 123-138.
  41. Boulanger, C.M. (1995) La NO synthase endotheliale. [Endothelial NO synthase] C. R. Seances Soc. Biol. Fil. 189, 1069-1079.
  42. Brann, D.W., Bhat, G.K., Lamar, C.A. and Mahesh, V.B. (1997) Gaseous transmitters and neuroendocrine regulation. Neuroendocrinology 65, 385-395.
  43. Bredt, D.S. (1996) Targeting nitric oxide to its targets. Proc. Soc. Exp. Biol. Med. 211, 41-48.
  44. Bredt, D.S. and Snyder, S.H. (1992) Nitric oxide, a novel neuronal messenger. Neuron 8, 3-11.
  45. Bredt, D.S. and Snyder, S.H. (1994) Nitric oxide: a physiologic messenger molecule. Annu. Rev. Biochem. 63, 175-195.
  46. Brenman, J.E. and Bredt, D.S. (1996) Nitric oxide signaling in the nervous system. Methods Enzymol. 269, 119-129.
  47. Brenman, J.E., Xia, H., Chao, D.S., Black, S.M. and Bredt, D.S. (1997) Regulation of neuronal nitric oxide synthase through alternative transcripts. Dev. Neurosci. 19, 224-231.
  48. Brenner, B.M. and Yu, A.S. (1992) Uremic syndrome revisited: A pathogenetic role for retained endogenous inhibitors of nitric oxide synthesis. Curr. Opin. Nephrol. Hypertens. 1, 3-7.
  49. Brookes, S.J. (1993) Neuronal nitric oxide in the gut. J. Gastroenterol. Hepatol. 8, 590-603.
  50. Brosnan, C.F., Battistini, L., Raine, C.S., Dickson, D.W., Casadevall, A. and Lee, S.C. (1994) Reactive nitrogen intermediates in human neuropathology: An overview. Dev. Neurosci. 16, 152-161.
  51. Brosnan, C.F., Lee, S.C. and Liu, J. (1997) Regulation of inducible nitric oxide synthase expression in human glia: Implications for inflammatory central nervous system diseases. Biochem. Soc. Trans. 25, 679-683.
  52. Brown, Z., Robson, R.L. and Westwick, J. (1993) L­Arginine/nitric oxide pathway: A possible signal transduction mechanism for the regulation of the chemokine IL­8 in human mesangial cells. Adv. Exp. Med. Biol. 351, 65-75.
  53. Busse, R. and Fleming, I. (1995) Regulation and functional consequences of endothelial nitric oxide formation. Ann. Med. 27, 331-340.
  54. Busse, R., Fleming, I. and Schini, V.B. (1995) Nitric oxide formation in the vascular wall: Regulation and functional implications. Curr. Top. Microbiol. Immunol. 196, 7-18.
  55. Cattell, V. and Cook, T. (1995) The nitric oxide pathway in glomerulonephritis. Curr. Opin. Nephrol. Hypertens. 4, 359-364.
  56. Cattell, V. and Jansen, A. (1995) Inducible nitric oxide synthase in inflammation. Histochem. J. 27, 777-784.
  57. Chan, P.H. (1996) Role of oxidants in ischemic brain damage. Stroke 27, 1124-1129.
  58. Chao, D.S., Hwang, P.M., Huang, F. and Bredt, D.S. (1996) Localization of neuronal nitric oxide synthase. Methods Enzymol. 268, 488-496.
  59. Charles, I.G., Scorer, C.A., Moro, M.A., Fernàndez, C., Chubb, A., Dawson, J., Foxwell, N., Knowles, R.G. and Baylis, S.A. (1996) Expression of human nitric oxide synthase isozymes. Methods Enzymol. 268, 449-460.
  60. Chayen, J., Bitensky, L. and Mehdizadeh, S. (1994) Histo­ and cytochemistry of guanylate cyclase and nitric oxide synthase: A critical appraisal. Cell Biochem. Funct. 12, 179-183.
  61. Chenais, B. and Tenu, J.P. (1994) Involvement of nitric oxide synthase in antiproliferative activity of macrophages: Induction of the enzyme requires two different kinds of signal acting synergistically. Int. J. Immunopharmacol. 16, 401-406.
  62. Christopherson, K.S. and Bredt, D.S. (1997) Nitric oxide in excitable tissues: Physiological roles and disease. J. Clin. Invest. 100, 2424-2429.
  63. Cifone, M.G., Cironi, L., Meccia, M.A., Roncaioli, P., Festuccia, C., De Nuntiis, G., D'Alo, S. and Santoni, A. (1995) Role of nitric oxide in cell­mediated tumor cytotoxicity. Adv. Neuroimmunol. 5, 443-461.
  64. Clark, I.A., al Yaman, F.M. and Jacobson, L.S. (1997) The biological basis of malarial disease. Int. J. Parasitol. 27, 1237-1249.
  65. Clarke, M.J. and Gaul, J.B. (1993) Chemistry relevant to the biological effects of nitric oxide and metallonitrosyls. Structure and Bonding 81, 147-181.
  66. Collin­Osdoby, P., Nickols, G.A. and Osdoby, P. (1995) Bone cell function, regulation, and communication: a role for nitric oxide. J. Cell Biochem. 57, 399-408.
  67. Colton, C.A. (1995) Induction of nitric oxide in cultured microglia: Evidence for a cytoprotective role. Adv. Neuroimmunol. 5, 491-503.
  68. Cooke, J.P. and Dzau, V.J. (1997) Nitric oxide synthase: role in the genesis of vascular disease. Annu. Rev. Med. 48, 489-509.
  69. Corbett, J.A. and McDaniel, M.L. (1992) Does nitric oxide mediate autoimmune destruction of ß­cells? Possible therapeutic interventions in IDDM. Diabetes 41, 897-903.
  70. Cosentino, F. and Luscher, T.F. (1998) Tetrahydrobiopterin and endothelial function. Eur. Heart J. 19, Suppl. G, G3-G8.
  71. Crossin, K.L. (1991) Nitric oxide (NO): a versatile second messenger in brain. Trends Biochem. Sci. 16, 81-82.
  72. Dalkara, T. and Moskowitz, M.A. (1994) The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia. Brain Pathol. 4, 49-57.
  73. Das, S. and Kumar, K.N. (1995) Nitric oxide: its identity and role in blood pressure control. Life Sci. 57, 1547-1556.
  74. Dawson, D.A. (1994) Nitric oxide and focal cerebral ischemia: Multiplicity of actions and diverse outcome. Cerebrovasc. Brain Metab. Rev. 6, 299-324.
  75. Dawson, T.M. and Dawson, V.L. (1994) gp120 neurotoxicity in primary cortical cultures. Adv. Neuroimmunol. 4, 167-173.
  76. Dawson, T.M. and Dawson, V.L. (1996a) Nitric oxide synthase: Role as a transmitter/mediator in the brain and endocrine system. Annu. Rev. Med. 47, 219-227.
  77. Dawson, T.M. and Dawson, V.L. (1996b) Generation of isoform­specific antibodies to nitric oxide synthases. Methods Enzymol. 268, 349-358.
  78. Dawson, T.M., Dawson, V.L. and Snyder, S.H. (1992) A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann. Neurol. 32, 297-311.
  79. Dawson, T.M., Dawson, V.L. and Snyder, S.H. (1993) Nitric oxide as a mediator of neurotoxicity. NIDA Res. Monogr. 136, 258-271.
  80. Dawson, T.M., Zhang, J., Dawson, V.L. and Snyder, S.H. (1994) Nitric oxide: cellular regulation and neuronal injury. Prog. Brain Res. 103, 365-369.
  81. Dawson, V.L. (1995) Nitric oxide: role in neurotoxicity. Clin. Exp. Pharmacol. Physiol. 22, 305-308.
  82. Dawson, V.L. and Dawson, T.M. (1995) Physiological and toxicological actions of nitric oxide in the central nervous system. Adv. Pharmacol. 34, 323-342.
  83. Dawson, V.L. and Dawson, T.M. (1996a) Nitric oxide neurotoxicity. J. Chem. Neuroanat. 10, 179-190.
  84. Dawson, V.L. and Dawson, T.M. (1996b) Nitric oxide actions in neurochemistry. Neurochem. Int. 29, 97-110.
  85. de Bel, E.E. (1994) Stikstofoxyde: nieuw licht op vele klinische syndromen. [Nitric oxide: a new light on many clinical syndromes] Ned. Tijdschr. Geneeskd. 138, 650-656.
  86. de Belder, A.J. and Radomski, M.W. (1994) Nitric oxide in the clinical arena. J. Hypertens. 12, 617-624.
  87. de Belder, A.J., Radomski, M.W., Martin, J.F. and Moncada, S. (1995) Nitric oxide and the pathogenesis of heart muscle disease. Eur. J. Clin. Invest. 25, 1-8.
  88. de Vera, M.E., Geller, D.A. and Billiar, T.R. (1995) Hepatic inducible nitric oxide synthase: regulation and function. Biochem. Soc. Trans. 23, 1008-1013.
  89. Dewanjee, M.K. (1997) Molecular biology of nitric oxide synthases. Reduction of complications of cardiopulmonary bypass from platelets and neutrophils by nitric oxide generation from L­arginine and nitric oxide donors. ASAIO J. 43, 151-159.
  90. Dietzschold, B. (1995) The role of nitric oxide in the pathogenesis of virus­induced encephalopathies. Curr. Top. Microbiol. Immunol. 196, 51-56.
  91. Dinerman, J.L., Lowenstein, C.J. and Snyder, S.H. (1993) Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease. Circ. Res. 73, 217-222.
  92. Dioh, A. and Hennen, G. (1995) Monoxyde d'azote. Donnees recentes sur la synthese et la genetique des nitric oxide synthases, regulation des fonctions hypothalamique et vasculaire. [Nitric oxide. Current findings on the synthesis and genetics of nitric oxide synthases, regulation of hypothalamic and vascular function] Rev. Med. Liege 50, 480-486.
  93. Di Rosa, M., Ialenti, A., Ianaro, A. and Sautebin, L. (1996) Interaction between nitric oxide and cyclooxygenase pathways. Prostaglandins, Leukot. Essent. Fatty Acids 54, 229-238.
  94. Do, K.Q., Benz, B., Grima, G., Gutteck­Amsler, U., Kluge, I. and Salt, T.E. (1996) Nitric oxide precursor arginine and S­nitrosoglutathione in synaptic and glial function Neurochem. Int. 29, 213-224.
  95. Dominiczak, A.F. and Bohr, D.F. (1995) Nitric oxide and its putative role in hypertension. Hypertension 25, 1202-1211.
  96. Dominiczak, A.F. and Bohr, D.F. (1996) Nitric oxide and hypertension in 1995. Curr. Opin. Nephrol. Hypertens. 5, 174-180.
  97. Drapier, J.­C. (1995) NO, effecteur ambivalent de l'immunite non specifique et de l'inflammation. [NO, ambivalent effector of non­specific immunity and of inflammation] C. R. Seances Soc. Biol. Fil. 189, 1081-1096.
  98. Drapier, J.­C. and Bouton, C. (1996) Modulation by nitric oxide of metalloprotein regulatory activities. BioEssays 18, 549-556.
  99. Dusting, G.J. (1995) Nitric oxide in cardiovascular disorders. J. Vasc. Res. 32, 143-161.
  100. Dusting, G.J. and Macdonald, P.S. (1995) Endogenous nitric oxide in cardiovascular disease and transplantation. Ann. Med. 27, 395-406.
  101. Edelstein, C.L., Yaqoob, M.M. and Schrier, R.W. (1996) The role of the calcium­dependent enzymes nitric oxide synthase and calpain in hypoxia­induced proximal tubule injury. Ren. Fail. 18, 501-511.
  102. Eizirik, D.L. and Leijerstam, F. (1994) The inducible form of nitric oxide synthase (iNOS) in insulin­producing cells. Diabete Metab. 20, 116-122.
  103. Eizirik, D.L., Flodström, M., Karlsen, A.E. and Welsh, N. (1996) The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic ß cells. Diabetologia 39, 875-890.
  104. Evans, C.H. (1995) Nitric oxide: what role does it play in inflammation and tissue destruction? Agents Actions Suppl. 47, 107-116.
  105. Evans, C.H., Stefanovic­Racic, M. and Lancaster, J. (1995) Nitric oxide and its role in orthopaedic disease. Clin. Orthop. 312, 275-294.
  106. Evans, D.M. and Ralston, S.H. (1996) Nitric oxide and bone. J. Bone Miner. Res. 11, 300-305.
  107. Faraci, F.M. and Brian, J.E., Jr. (1994) Nitric oxide and the cerebral circulation. Stroke 25, 692-703.
  108. Farhat, M.Y., Lavigne, M.C. and Ramwell, P.W. (1996) The vascular protective effects of estrogen. FASEB J. 10, 615-624.
  109. Feinstein, D.L., Galea, E. and Reis, D.J. (1994) Suppression of glial iNOS expression by tyrosine kinase inhibitors. Ann. N. Y. Acad. Sci. 738, 325-328.
  110. Felley­Bosco, E. (1995) Species specificity at the molecular level: The case of nitric oxide synthases. Arch. Toxicol. Suppl. 17, 357-366.
  111. Fleming, I. and Busse, R. (1995) Control and consequences of endothelial nitric oxide formation. Adv. Pharmacol. 34, 187-206.
  112. Fleming, I., Bauersachs, J. and Busse, R. (1997) Calcium­dependent and calcium­independent activation of the endothelial NO synthase. J. Vasc. Res. 34, 165-174.
  113. Förstermann, U. (1994) Biochemistry and molecular biology of nitric oxide synthases. Arzneimittelforschung 44, 402-407.
  114. Förstermann, U. and Kleinert, H. (1995) Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn Schmiedebergs Arch. Pharmacol. 352, 351-364.
  115. Förstermann, U. and Dun, N.J. (1996) Immunohistochemical localization of nitric oxide synthases. Methods Enzymol. 268, 510-515.
  116. Förstermann, U. and Gath, I. (1996) Purification of isoforms of nitric oxide synthase. Methods Enzymol. 268, 334-339.
  117. Förstermann, U., Schmidt, H.H., Pollock, J.S., Sheng, H., Mitchell, J.A., Warner, T.D., Nakane, M. and Murad, F. (1991) Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem. Pharmacol. 42, 1849-1857.
  118. Förstermann, U., Nakane, M., Tracey, W.R. and Pollock, J.S. (1993) Isoforms of nitric oxide synthase: functions in the cardiovascular system. Eur. Heart J. 14 Suppl. I, 10-15.
  119. Förstermann, U., Closs, E.I., Pollock, J.S., Nakane, M., Schwarz, P., Gath, I. and Kleinert, H. (1994) Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions. Hypertension 23, 1121-1131.
  120. Förstermann, U., Gath, I., Schwarz, P., Closs, E.I. and Kleinert, H. (1995a) Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control. Biochem. Pharmacol. 50, 1321-1332.
  121. Förstermann, U., Kleinert, H., Gath, I., Schwarz, P., Closs, E.I. and Dun, N.J. (1995b) Expression and expressional control of nitric oxide synthases in various cell types. Adv. Pharmacol. 34, 171-186.
  122. Franchini, A., Conte, A. and Ottaviani, E. (1995) Nitric oxide: an ancestral immunocyte effector molecule. Adv. Neuroimmunol. 5, 463-478.
  123. Fukuto, J.M. (1996) Chemistry of N­hydroxy­L­arginine. Methods Enzymol. 268, 365-375.
  124. Fukuto, J.M. and Chaudhuri, G. (1995) Inhibition of constitutive and inducible nitric oxide synthase: Potential selective inhibition. Annu. Rev. Pharmacol. Toxicol. 35, 165-194.
  125. Garini, G., Savazzi, G. and Borghetti, A. (1997) II sistema L­arginina-ossido nitrico. Fisiologia, fisiopatologia e rilevanza clinica. [The L­arginine-nitric oxide system: Physiology, physiopathology and clinical relevance.] Recenti Prog. Med. 88, 90-99.
  126. Garthwaite, J. and Boulton, C.L. (1995) Nitric oxide signaling in the central nervous system. Annu. Rev. Physiol. 57, 683-706.
  127. Garvey, E.P., Furfine, E.S. and Sherman, P.A. (1996) Purification and inhibitor screening of human nitric oxide synthase isozymes. Methods Enzymol. 268, 339-349.
  128. Gaston, B., Drazen, J.M., Loscalzo, J. and Stamler, J.S. (1994) The biology of nitrogen oxides in the airways. Am. J. Respir. Crit. Care Med. 149, 538-551.
  129. Geller, D.A. and Billiar, T.R. (1993) Should surgeons clone genes? The strategy behind the cloning of the human inducible nitric oxide synthase gene. Arch. Surg. 128, 1212-1220.
  130. Gibson, A. and Lilley, E. (1997) Superoxide anions, free­radical scavengers, and nitrergic neurotransmission. Gen. Pharmacol. 28, 489-493.
  131. Gibson, A., Brave, S.R., McFadzean, I., Tucker, J.F. and Wayman, C. (1995) The nitrergic transmitter of the anococcygeus - NO or not? Arch. Int. Pharmacodyn. Ther. 329, 39-51.
  132. Goldstein, I.M., Ostwald, P. and Roth, S. (1996) Nitric oxide: a review of its role in retinal function and disease. Vision Res. 36, 2979-2994.
  133. Gorren, A.C.F. and Mayer, B. (1998) The versatile and complex enzymology of nitric oxide synthase. Biochemistry (Moscow) 63, 734-743 (English); Biokhimiia (Moscow) 63, 870-880 (Russian).
  134. Gothberg, G. (1994) Physiology of the renomedullary depressor system. J. Hypertens. 12, S57-S64.
  135. Green, I.C., Cunningham, J.M., Delaney, C.A., Elphick, M.R., Mabley, J.G. and Green, M.H. (1994) Effects of cytokines and nitric oxide donors on insulin secretion, cyclic GMP and DNA damage: relation to nitric oxide production. Biochem. Soc. Trans. 22, 30-37.
  136. Green, S.J., Scheller, L.F., Marletta, M.A., Seguin, M.C., Klotz, F.W., Slayter, M., Nelson, B.J. and Nacy, C.A. (1994) Nitric oxide: cytokine­regulation of nitric oxide in host resistance to intracellular pathogens. Immunol. Lett. 43, 87-94.
  137. Griffith, O.W. and Kilbourn, R.G. (1996) Nitric oxide synthase inhibitors: amino acids. Methods Enzymol. 268, 375-392.
  138. Griffith, O.W. and Kilbourn, R.G. (1997) Design of nitric oxide synthase inhibitors and their use to reverse hypotension associated with cancer immunotherapy. Adv. Enzyme Regul. 37, 171-194.
  139. Griffith, O.W. and Stuehr, D.J. (1995) Nitric oxide synthases: properties and catalytic mechanism. Annu. Rev. Physiol. 57, 707-736.
  140. Griscavage, J.M., Hobbs, A.J. and Ignarro, L.J. (1995) Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds. Adv. Pharmacol. 34, 215-234.
  141. Gross, S.S. and Wolin, M.S. (1995) Nitric oxide: pathophysiological mechanisms. Annu. Rev. Physiol. 57, 737-769.
  142. Gross, S.S., Levi, R., Madera, A., Park, K.H., Vane, J. and Hattori, Y. (1993) Tetrahydrobiopterin synthesis is induced by LPS in vascular smooth muscle and is rate­limiting for nitric oxide production. Adv. Exp. Med. Biol. 338, 295-300.
  143. Gryglewski, R.J. (1993) Interactions between nitric oxide and prostacyclin. Semin. Thromb. Hemost. 19, 158-166.
  144. Harrison, D.G. (1994) Endothelial dysfunction in atherosclerosis. Basic Res. Cardiol. 89 Suppl. 1, 87-102.
  145. Harrison, D.G. (1997) Cellular and molecular mechanisms of endothelial cell dysfunction. J. Clin. Invest. 100, 2153-2157.
  146. Harrison, D.G., Venema, R.C., Arnal, J.F., Inoue, N., Ohara, Y., Sayegh, H. and Murphy, T.J. (1995) The endothelial cell nitric oxide synthase: is it really constitutively expressed? Agents Actions Suppl. 45, 107-117.
  147. Harrison, D.G., Sayegh, H., Ohara, Y., Inoue, N. and Venema, R.C. (1996a) Regulation of expression of the endothelial cell nitric oxide synthase. Clin. Exp. Pharmacol. Physiol. 23, 251-255.
  148. Harrison, D.G., Inoue, N., Ohara, Y. and Fukai, T. (1996b) Modulation of endothelial cell nitric oxide synthase expression. Jpn. Circ. J. 60, 815-821.
  149. Hartmann, B., Ngezahayo, A., Heller, B., Jalowy, A., Burkart, V., Kolb, H.A. and Kolb, H. (1994) Nitric oxide toxicity in pancreatic islet cells: Role of protein biosynthesis, calcium influx and arachidonic acid metabolism. Biochem. Soc. Trans. 22, 23-26.
  150. Hattori, R., Sase, K., Eizawa, H., Kosuga, K., Aoyama, T., Inoue, R., Sasayama, S., Kawai, C., Yui, Y., Miyahara, K. and Shizuta, Y. (1994) Structure and function of nitric oxide synthases. Int. J. Cardiol. 47, S71-S75 [published erratum Int. J. Cardiol. 51, 107 (1995)].
  151. Haulica, I., Petrescu, G. and Slatineanu, S. (1994) Preocupations actuelles concernant le monoxide d'azote en tant que messager neuronal. [Current information on nitric oxide as a neuronal messenger] Rom. J. Physiol. 31, 3-12.
  152. Heales, S.J., Barker, J.E., Stewart, V.C., Brand, M.P., Hargreaves, I.P., Foppa, P., Land, J.M., Clark, J.B. and Bolanos, J.P. (1997) Nitric oxide, energy metabolism and neurological disease. Biochem. Soc. Trans. 25, 939-943.
  153. Henry, Y., Ducrocq, C., Drapier, J.­C., Servent, D., Pellat, C. and Guissani, A. (1991) Nitric oxide, a biological effector. Electron paramagnetic resonance detection of nitrosyl-iron-protein complexes in whole cells. Eur. Biophys. J. 20, 1-15.
  154. Herman, B.H., Vocci, F. and Bridge, P. (1995) The effects of NMDA receptor antagonists and nitric oxide synthase inhibitors on opioid tolerance and withdrawal. Medication development issues for opiate addiction. Neuropsychopharmacology 13, 269-293.
  155. Higenbottam, T. and Cremona, G. (1993) Acute and chronic hypoxic pulmonary hypertension. Eur. Respir. J. 6, 1207-1212.
  156. Hokfelt, T., Ceccatelli, S., Gustafsson, L., Hulting, A.L., Verge, V., Villar, M., Xu, X.J., Xu, Z.Q., Wiesenfeld­Hallin, Z. and Zhang, X. (1994) Plasticity of NO synthase expression in the nervous and endocrine systems. Neuropharmacology 33, 1221-1227.
  157. Holstad, M., Jansson, L. and Sandler, S. (1997) Inhibition of nitric oxide formation by aminoguanidine: An attempt to prevent insulin­dependent diabetes mellitus. Gen. Pharmacol. 29, 697-700.
  158. Holtz, J. and Goetz, R.M. (1994) The endothelium and the renin-angiotensin system. Arzneimittelforschung 44, 397-402.
  159. Howarth, P.H., Redington, A.E., Springall, D.R., Martin, U., Bloom, S.R., Polak, J.M. and Holgate, S.T. (1995) Epithelially derived endothelin and nitric oxide in asthma. Int. Arch. Allergy Immunol. 107, 228-230.
  160. Hu, J. and el­Fakahany, E.E. (1996) Intricate regulation of nitric oxide synthesis in neurons. Cell Signal. 8, 185-189.
  161. Huang, E.P. (1997) Synaptic plasticity: A role for nitric oxide in LTP. Curr. Biol. 7, R141-R143.
  162. Huang, P.L. and Fishman, M.C. (1997) Genetic analysis of nitric oxide synthase isoforms: Targeted mutation in mice. J. Mol. Med. 74, 415-421.
  163. Iadecola, C., Pelligrino, D.A., Moskowitz, M.A. and Lassen, N.A. (1994) Nitric oxide synthase inhibition and cerebrovascular regulation. J. Cereb. Blood Flow Metab. 14, 175-192.
  164. Ignarro, L.J. (1990) Nitric oxide. A novel signal transduction mechanism for transcellular communication. Hypertension 16, 477-483.
  165. Ignarro, L.J. (1993) Nitric oxide­mediated vasorelaxation. Thromb. Haemost. 70, 148-151.
  166. Ignarro, L.J. (1996) Physiology and pathophysiology of nitric oxide. Kidney Int. 55, S2-S5.
  167. Ikeda, U. and Shimada, K. (1997) Nitric oxide and cardiac failure. Clin. Cardiol. 20, 837-841.
  168. Ingram, D.K., Spangler, E.L., Iijima, S., Ikari, H., Kuo, H., Greig, N.H. and London, E.D. (1994) Rodent models of memory dysfunction in Alzheimer's disease and normal aging: Moving beyond the cholinergic hypothesis. Life Sci. 55, 2037-2049.
  169. Ito, S. (1995) Nitric oxide in the kidney. Curr. Opin. Nephrol. Hypertens. 4, 23-30.
  170. Ito, S., Carretero, O.A. and Abe, K. (1995) Nitric oxide in the regulation of renal blood flow. New Horiz. 3, 615-623.
  171. Ito, S., Carretero, O.A. and Abe, K. (1997) Role of nitric oxide in the control of glomerular microcirculation. Clin. Exp. Pharmacol. Physiol. 24, 578-581.
  172. Jaffrey, S.R. and Snyder, S.H. (1995) Nitric oxide: a neural messenger. Ann. Rev. Cell Dev. Biol. 11, 417-440.
  173. Jensen, B.O. and Holmsen, H. (1992) Fra endotelderivert relakserende faktor til L­arginin og nitrogen monoksid. [From endothelium­derived relaxing factor to L­arginine and nitrogen monoxide] Tidsskr. Nor. Laegeforen 112, 2531-2535.
  174. Johansson, K.U. and Carlberg, M. (1995) NO­synthase: what can research on invertebrates add to what is already known? Adv. Neuroimmunol. 5, 431-442.
  175. Johns, R.A. (1993) Endothelium, anesthetics, and vascular control. Anesthesiology 79, 1381-1391.
  176. Jorens, P.G., Vermeire, P.A. and Herman, A.G. (1993) L­arginine-dependent nitric oxide synthase: A new metabolic pathway in the lung and airways. Eur. Respir. J. 6, 258-266.
  177. Katusic, Z.S. (1992) Role of nitric oxide signal transduction pathway in regulation of vascular tone. Int. Angiol. 11, 14-19.
  178. Kawashima, S., Hirata, K., Katayama, M., Miki, N., Suematsu, M. and Yokoyama, M. (1993) Regulatory mechanisms of endothelial nitric oxide synthase activity and its modification by lipids and cytokines. Jpn. Circ. J. 57 Suppl. 4, 1193-1197.
  179. Kerwin, J.F., Jr. and Heller, M. (1994) The arginine-nitric oxide pathway: a target for new drugs. Med. Res. Rev. 14, 23-74.
  180. Keusch, G.T. (1993) Antioxidants in infection. J. Nutr. Sci. Vitaminol. (Tokyo) 39, S23-S33.
  181. Kiechle, F.L. and Malinski, T. (1993) Nitric oxide. Biochemistry, pathophysiology, and detection. Am. J. Clin. Pathol. 100, 567-575.
  182. Kilbourn, R.G. (1991) Regulation of nitric oxide biosynthesis: Cofactor requirement and enzymatic characteristics. Res. Immunol. 142, 587-588.
  183. Kilbourn, R.G. and Griffith, O.W. (1992) Overproduction of nitric oxide in cytokine­mediated and septic shock. J. Natl. Cancer Inst. 84, 827-831.
  184. Kilbourn, R.G., Szabo, C. and Traber, D.L. (1997) Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: Lessons learned from experimental and clinical studies. Shock 7, 235-246.
  185. King, R.G., Gude, N.M., Di Iulio, J.L. and Brennecke, S.P. (1995) Regulation of human placental fetal vessel tone: Role of nitric oxide. Reprod. Fertil. Dev. 7, 1407-1411.
  186. Klatt, P., Schmidt, K., Werner, E.R. and Mayer, B. (1996) Determination of nitric oxide synthase cofactors: Heme, FAD, FMN, and tetrahydrobiopterin. Methods Enzymol. 268, 358-365.
  187. Knowles, R.G. (1997) Nitric oxide biochemistry. Biochem. Soc. Trans. 25, 895-901.
  188. Knowles, R.G. and Moncada, S. (1992) Nitric oxide as a signal in blood vessels. Trends Biochem. Sci. 17, 399-402.
  189. Knowles, R.G. and Moncada, S. (1994) Nitric oxide synthases in mammals. Biochem. J. 298, 249-258.
  190. Kolb, E. (1991) Neuere Erkenntnisse zur Bildung von Stickstoffoxid in Endothelzellen der Gefasse, in Nervenzellen und Makrophagen sowie zu seiner Bedeutung bei der Gefasserweiterung, der Informationsubermittlung bzw. der Schadigung von Tumorzellen. [Current knowledge on the formation of nitric oxide in endothelial cells of blood vessels, in nerve cells and macrophages as well as its significance in vascular dilatation, information transmission and damage of tumor cells] Z. Gesamte Inn. Med. 46, 431-436.
  191. Kolb, H. and Kolb­Bachofen, V. (1992) Nitric oxide: a pathogenetic factor in autoimmunity. Immunol. Today 13, 157-160.
  192. Kolb­Bachofen, V. (1996) Intraislet expression of inducible nitric oxide synthase and islet cell death. Biochem. Soc. Trans. 24, 233-234.
  193. Kone, B.C. (1997) Nitric oxide in renal health and disease. Am. J. Kidney Dis. 30, 311-333.
  194. Kröncke, K.­D., Fehsel, K. and Kolb­Bachofen, V. (1995) Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities. Biol. Chem. Hoppe­Seyler 376, 327-343.
  195. Lees, G.J. (1993) The possible contribution of microglia and macrophages to delayed neuronal death after ischemia. J. Neurol. Sci. 114, 119-122.
  196. Libby, P., Sukhova, G., Lee, R.T. and Galis, Z.S. (1995) Cytokines regulate vascular functions related to stability of the atherosclerotic plaque. J. Cardiovasc. Pharmacol. 25 Suppl. 2, S9-S12.
  197. Liegeois, J.F. and Damas, J. (1993) Un messager intercellulaire original, le NO (monoxyde d'azote). [An original intercellular messenger, NO] Rev. Med. Liege 48, 406-413.
  198. Liew, F.Y. (1993) The role of nitric oxide in parasitic diseases. Ann. Trop. Med. Parasitol. 87, 637-642.
  199. Liew, F.Y. (1995) Interactions between cytokines and nitric oxide. Adv. Neuroimmunol. 5, 201-209.
  200. Liew, F.Y. and Cox, F.E. (1991) Nonspecific defence mechanism: the role of nitric oxide. Immunol. Today. 12, A17-A21.
  201. Liew, F.Y., Wei, X.Q. and Proudfoot, L. (1997) Cytokines and nitric oxide as effector molecules against parasitic infections. Philos. Trans. R. Soc. Lond. B 352, 1311-1315.
  202. Liu, Q. and Gross, S.S. (1996) Binding sites of nitric oxide synthases. Methods Enzymol. 268, 311-324.
  203. London, E.D., Kimes, A.S. and Vaupel, D.B. (1995) Inhibitors of nitric oxide synthase and the opioid withdrawal syndrome. NIDA Res. Monogr. 147, 170-181.
  204. Lopez­Figueroa, M.O. and Moller, M. (1996) Nitric oxide synthase in the pineal gland. Histol. Histopathol. 11, 1089-1100.
  205. Lowenstein, C.J. and Snyder, S.H. (1992) Nitric oxide, a novel biologic messenger. Cell 70, 705-707.
  206. Lowenstein, C.J., Dinerman, J.L. and Snyder, S.H. (1994) Nitric oxide: a physiologic messenger. Ann. Intern. Med. 120, 227-237.
  207. Lugg, J.A., Gonzalez­Cadavid, N.F. and Rajfer, J. (1995) The role of nitric oxide in erectile function. J. Androl. 16, 2-4.
  208. Luscher, T.F. (1992) Endogenous and exogenous nitrates and their role in myocardial ischaemia. Br. J. Clin. Pharmacol. 34 Suppl. 1, 29S-35S.
  209. Lynch, D.R. and Dawson, T.M. (1994) Secondary mechanisms in neuronal trauma. Curr. Opin. Neurol. 7, 510-516.
  210. MacAllister, R. and Vallance, P. (1994) Nitric oxide in essential and renal hypertension. J. Am. Soc. Nephrol. 5, 1057-1065.
  211. McAndrew, J., Patel, R.P., Jo, H., Cornwell, T., Lincoln, T., Moellering, D., White, C.R., Matalon, S. and Darley­Usmar, V. (1997) The interplay of nitric oxide and peroxynitrite with signal transduction pathways: implications for disease. Semin. Perinatol. 21, 351-366.
  212. McDaniel, M.L., Kwon, G., Hill, J.R., Marshall, C.A. and Corbett, J.A. (1996) Cytokines and nitric oxide in islet inflammation and diabetes. Proc. Soc. Exp. Biol. Med. 211, 24-32.
  213. MacMicking, J., Xie, Q.­w. and Nathan, C.F. (1997) Nitric oxide and macrophage function. Annu. Rev. Immunol. 15, 323-350.
  214. McMillan, K., Salerno, J.C. and Masters, B.S.S. (1996) Nitric oxide synthases: Analogies to cytochrome P450 monooxygenases and characterization of recombinant rat neuronal nitric oxide synthase hemoprotein. Methods Enzymol. 268, 460-472.
  215. Madan, G. and Rao, M. (1996) Physiological and clinical importance of nitric oxide. Indian. J. Med. Sci. 50, 318-324.
  216. Madison, D.V. (1993) Pass the nitric oxide. Proc. Natl. Acad. Sci. USA 90, 4329-4331.
  217. Maeda, H. and Akaike, T. (1998) Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Moscow) 63, 854-865 (English); Biokhimiia (Moscow) 63, 1007-1019 (Russian).
  218. Maeda, H., Akaike, T., Yoshida, M., Sato, K. and Noguchi, Y. (1995) A new nitric oxide scavenger, imidazolineoxyl N­oxide derivative, and its effects in pathophysiology and microbiology. Curr. Top. Microbiol. Immunol. 196, 37-50.
  219. Magazine, H.I. (1995) Detection of endothelial cell­derived nitric oxide: Current trends and future directions. Adv. Neuroimmunol. 5, 479-490.
  220. Maines, M.D. (1996) Carbon monoxide and nitric oxide homology: Differential modulation of heme oxygenases in brain and detection of protein and activity. Methods Enzymol. 268, 473-488.
  221. Mansuy, D., Boucher, J.­L. and Clement, B. (1995) On the mechanism of nitric oxide formation upon oxidative cleavage of C=N(OH) bonds by NO­synthases and cytochromes P450. Biochimie 77, 661-667.
  222. Markov, Kh.M. (1996) The bioregulatory system L­arginine-nitric oxide. Patol. Fiziol. Eksp. Ter. (Moscow) 1, 34-39.
  223. Marletta, M.A. (1993a) Nitric oxide synthase structure and mechanism. J. Biol. Chem. 268, 12231-12234.
  224. Marletta, M.A. (1993b) Nitric oxide synthase: function and mechanism. Adv. Exp. Med. Biol. 338, 281-284.
  225. Marletta, M.A. (1994a) Approaches toward selective inhibition of nitric oxide synthase. J. Med. Chem. 37, 1899-1907.
  226. Marletta, M.A. (1994b) Nitric oxide synthase: aspects concerning structure and catalysis. Cell 78, 927-930.
  227. Marletta, M.A., Hurshman, A.R. and Rusche, K.M. (1998) Catalysis by nitric oxide synthase. Curr. Opin. Chem. Biol. 2, 656-663.
  228. Martinez, A. (1995) Nitric oxide synthase in invertebrates. Histochem. J. 27, 770-776.
  229. Mascotti, D.P., Rup, D. and Thach, R.E. (1995) Regulation of iron metabolism: translational effects mediated by iron, heme, and cytokines. Annu. Rev. Nutr. 15, 239-261.
  230. Masters, B.S.S. (1994) Nitric oxide synthases: why so complex? Annu. Rev. Nutr. 14, 131-145.
  231. Masters, B.S.S., McMillan, K., Sheta, E., Nishimura, J., Roman, L.J. and Martásek, P. (1996a) Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: Structure studies of a cysteine thiolate­liganded heme protein that hydroxylates L­arginine to produce NO· as a cellular signal. FASEB J. 10, 552-558.
  232. Masters, B.S.S., McMillan, K., Nishimura, J., Martásek, P., Roman, L.J., Sheta, E., Gross, S.S. and Salerno, J. (1996b) Understanding the structural aspects of neuronal nitric oxide synthase (NOS) using microdissection by molecular cloning techniques: Molecular dissection of neuronal NOS. Adv. Exp. Med. Biol. 387, 163-169.
  233. Mayer, B. (1994a) Regulation of nitric oxide synthase and soluble guanylyl cyclase. Cell Biochem. Funct. 12, 167-177.
  234. Mayer, B. (1994b) Nitric oxide/cyclic GMP­mediated signal transduction. Ann. N. Y. Acad. Sci. 733, 357-364.
  235. Mayer, B. and Andrew, P. (1998) Nitric oxide synthases: catalytic function and progress towards selective inhibition. Naunyn Schmiedebergs Arch. Pharmacol. 358, 127-133.
  236. Mayer, B. and Hemmens, B. (1997) Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem. Sci. 22, 477-481.
  237. Mayer, B. and Werner, E.R. (1995a) In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide. Naunyn Schmiedebergs Arch. Pharmacol. 351, 453-463.
  238. Mayer, B. and Werner, E.R. (1995b) Why tetrahydrobiopterin? Adv. Pharmacol. 34, 251-261.
  239. Mayer, B., Koesling, D. and Bohme, E. (1993) Characterization of nitric oxide synthase, soluble guanylyl cyclase, and Ca2+/calmodulin­stimulated cGMP phosphodiesterase as components of neuronal signal transduction. Adv. Second Messenger Phosphoprotein Res. 28, 111-119.
  240. Mayer, B., Klatt, P., List, B., Harteneck, C. and Schmidt, K. (1996) Large­scale purification of rat brain nitric oxide synthase from baculovorus overexpression system. Methods Enzymol. 268, 420-427.
  241. Melis, M.R. and Argiolas, A. (1997) Role of central nitric oxide in the control of penile erection and yawning. Prog. Neuropsychopharmacol. Biol. Psychiatry. 21, 899-922.
  242. Mendez­Otero, R., Tenorio, F., Giraldi­Guimaraes, A., Soares, M., Batista, C.M., Santos, H.R., Cintra, W.M., Moritz, G., Allodi, S., Masuda, H.P. and Brazil­Mas, L. (1996) Patterns of nitric oxide synthase expression in the developing superior colliculus. Rev. Bras. Biol. 56 Suppl. 1:1, 113-122.
  243. Mengozzi, G., Veglio, F., Schiavone, D., Inconis, T., Mulatero, P. and Paradisi, L. (1996) La via metabolica L­arginina/ossido di azoto. Fisiopatologia ed implicazioni cliniche. [The L­arginine/nitric oxide metabolic pathway. Its physiopathology and clinical implications] Ann. Ital. Med. Int. 11, 46-51.
  244. Merritt, W.T. (1993) Nitric oxide: an important bioregulator. Transplant. Proc. 25, 2014-2016.
  245. Michel, T. and Feron, O. (1997) Nitric oxide synthases: which, where, how, and why? J. Clin. Invest. 100, 2146-2152.
  246. Michel, T. and Smith, T.W. (1993) Nitric oxide synthases and cardiovascular signaling. Am. J. Cardiol. 72, 33C-38C.
  247. Mittal, C.K. (1995) Oxygen­radical/nitric oxide mediate calcium­dependent hormone action on cyclic GMP system: A novel concept in signal transduction mechanisms. Mol. Cell. Biochem. 149-150, 257-262.
  248. Mittal, C.K. and Mehta, C.S. (1995) Regulation of nitric oxide synthase: Role of oxygen radicals and cations in nitric oxide formation. Adv. Pharmacol. 34, 235-250.
  249. Mize, R.R., Banfro, F.T. and Scheiner, C.A. (1996) Pre­ and postnatal expression of amino acid neurotransmitters, calcium binding proteins, and nitric oxide synthase in the developing superior colliculus. Prog. Brain Res. 108, 313-332.
  250. Mollace, V. and Nistico, G. (1995) Release of nitric oxide from astroglial cells: A key mechanism in neuroimmune disorders. Adv. Neuroimmunol. 5, 421-430.
  251. Mombouli, J.V. and Vanhoutte, P.M. (1995) Endothelium­derived hyperpolarizing factor(s) and the potentiation of kinins by converting enzyme inhibitors. Am. J. Hypertens. 8, 19S-27S.
  252. Moncada, S. (1992) The 1991 Ulf von Euler Lecture. The L­arginine:nitric oxide pathway. Acta Physiol. Scand. 145, 201-227.
  253. Moncada, S. (1993) Bedeutung der endogenen Nitric­Oxide­Produktion fur die Wirkung von Nitraten und bei septischem Schock. [Significance of endogenous nitric oxide production for the effect of nitrates and in septic shock] Schweiz Rundsch. Med. Prax. 82, 1154-1160.
  254. Moncada, S. (1994a) The "Sanchez­Medal" Lecture Award: Nitric oxide 1994. Rev. Invest. Clin. Suppl., 15-17.
  255. Moncada, S. (1994b) Nitric oxide. J. Hypertens. 12, S35-S39.
  256. Moncada, S. and Higgs, E.A. (1991) Endogenous nitric oxide: Physiology, pathology and clinical relevance. Eur. J. Clin. Invest. 21, 361-374.
  257. Moncada, S. and Higgs, E.A. (1993) The L­arginine-nitric oxide pathway. New Engl. J. Med. 329, 2002-2012.
  258. Moncada, S. and Higgs, E.A. (1995) Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J. 9, 1319-1330.
  259. Moncada, S. and Palmer, R.M. (1991) Inhibition of the induction of nitric oxide synthase by glucocorticoids: yet another explanation for their anti­inflammatory effects? Trends Pharmacol. Sci. 12, 130-131.
  260. Moncada, S., Higgs, E.A. and Furchgott, R. (1997) International Union of Pharmacology Nomenclature in Nitric Oxide Research. Pharmacol. Rev. 49, 137-142.
  261. Moore, P.K. and Bland­Ward, P.A. (1996) 7­Nitroindazole: An inhibitor of nitric oxide synthase. Methods Enzymol. 268, 393-398.
  262. Moore, P.K. and Handy, R.L. (1997) Selective inhibitors of neuronal nitric oxide synthase - Is no NOS really good NOS for the nervous system? Trends Pharmacol. Sci. 18, 204-211.
  263. Moroz, L.L. and Gillette, R. (1995) From Polyplacophora to Cephalopoda: comparative analysis of nitric oxide signalling in mollusca. Acta Biol. Hung. 46, 169-182.
  264. Mourelle Mancini, M. (1995) El oxido nitrico: mediador no adrenergico-no colinergico en el tubo digestivo. [Nitric oxide: a nonadrenergic, noncholinergic mediator in the digestive system] Gastroenterol. Hepatol. 18, 334-339.
  265. Müller, U. (1997) The nitric oxide system in insects. Prog. Neurobiol. 51, 363-381.
  266. Mugge, A. (1994) Abnorme Endothel­vermittelte Regulation des Gefasstonus bei Arteriosklerose. [Abnormal endothelium-mediated regulation of vascular tone in arteriosclerosis] Z. Kardiol. 83, 759-767.
  267. Mulsch, A. (1991) NO synthases: mechanism of activation, identity of NOX and expression in human cells. Res. Immunol. 142, 561-565.
  268. Murad, F. (1994) The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular communication. Recent Prog. Horm. Res. 49, 239-248.
  269. Murad, F., Förstermann, U., Nakane, M., Pollock, J.S., Tracey, W.R., Matsumoto, T. and Buechler, W. (1993) The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular communication. Adv. Second Messenger Phosphoprotein Res. 28, 101-109.
  270. Murphy, S. and Simmons, M.L. (1992) The role of polyphosphoinositides in agonist­evoked release of vasoactive factors from astrocytes. Prog. Brain Res. 94, 153-162.
  271. Murphy, S., Simmons, M.L., Agullo, L., Garcia, A., Feinstein, D.L., Galea, E., Reis, D.J., Minc­Golomb, D. and Schwartz, J.P. (1993) Synthesis of nitric oxide in CNS glial cells. Trends Neurosci. 16, 323-328.
  272. Nadaud, S. and Soubrier, F. (1995) Biologie moléculaire et génétique des NO synthases. [Molecular biology and genetics of NO synthases] C. R. Seances Soc. Biol. Fil. 189, 1025-1038.
  273. Nadaud, S. and Soubrier, F. (1996) Molecular biology and molecular genetics of nitric oxide synthase genes. Clin. Exp. Hypertens. 18, 113-143.
  274. Nakaki, T. and Kato, R. (1994) Beneficial circulatory effect of L­arginine. Jpn. J. Pharmacol. 66, 167-171.
  275. Nathan, C.F. (1992) Nitric oxide as a secretory product of mammalian cells. FASEB J. 6, 3051-3064.
  276. Nathan, C.F. (1995) Inducible nitric oxide synthase: regulation subserves function. Curr. Top. Microbiol. Immunol. 196, 1-4.
  277. Nathan, C.F. (1997) Inducible nitric oxide synthase: what difference does it make? J. Clin. Invest. 100, 2417-2423.
  278. Nathan, C.F. and Hibbs, J.B., Jr. (1991) Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol. 3, 65-70.
  279. Nathan, C.F. and Stuehr, D.J. (1990) Does endothelium­derived nitric oxide have a role in cytokine­induced hypotension? J. Natl. Cancer Inst. 82, 726-728.
  280. Nathan, C.F. and Xie, Q.­w. (1994a) Regulation of biosynthesis of nitric oxide. J. Biol. Chem. 269, 13725-13728.
  281. Nathan, C.F. and Xie, Q.­w. (1994b) Nitric oxide synthase: roles, tolls, and controls. Cell 78, 915-918.
  282. Nava, E., Noll, G. and Luscher, T.F. (1995) Nitric oxide in cardiovascular diseases. Ann. Med. 27, 343-351.
  283. Nedospasov, A.A. (1998) Competition involving biogenic NO. Biochemistry (Moscow) 63, 744-765 (English); Biokhimiia (Moscow) 63, 881-904 (Russian).
  284. Neri, I., Di Renzo, G.C., Caserta, G., Gallinelli, A. and Facchinetti, F. (1995) Impact of the L­arginine/nitric oxide system in pregnancy. Obstet. Gynecol. Surv. 50, 851-858.
  285. Nicotera, P., Bonfoco, E. and Brune, B. (1995) Mechanisms for nitric oxide­induced cell death: Involvement of apoptosis. Adv. Neuroimmunol. 5, 411-420.
  286. Nijkamp, F.P. and Folkerts, G. (1995) Nitric oxide and bronchial hyperresponsiveness. Arch. Int. Pharmacodyn. Ther. 329, 81-96.
  287. Noll, G., Tschudi, M., Nava, E. and Luscher, T.F. (1997) Endothelium and high blood pressure. Int. J. Microcirc. Clin. Exp. 17, 273-279.
  288. Norris, P.J., Charles, I.G., Scorer, C.A. and Emson, P.C. (1995) Studies on the localization and expression of nitric oxide synthase using histochemical techniques. Histochem. J. 27, 745-756.
  289. Nomura, Y. and Kitamura, Y. (1993) Inducible nitric oxide synthase in glial cells. Neurosci. Res. 118, 103-107.
  290. Nussler, A.K. and Billiar, T.R. (1993) Inflammation, immunoregulation, and inducible nitric oxide synthase. J. Leukoc. Biol. 54, 171-178.
  291. Nussler, A.K., Heeckt, P.F. and Stadler, J. (1994) Metabolismus und Funktion von Nitric oxide in der Leber. [Metabolism and function of nitric oxide in the liver] Z. Gastroenterol. 32, 24-30.
  292. Ogden, J.E. and Moore, P.K. (1995) Inhibition of nitric oxide synthase - potential for a novel class of therapeutic agent? Trends Biotechnol. 13, 70-78.
  293. Oh, S. (1995) The generation of nitric oxide and its roles in neurotransmission and neurotoxicity. Keio J. Med. 44, 53-61.
  294. Olesen, J., Thomsen, L.L. and Iversen, H. (1994) Nitric oxide is a key molecule in migraine and other vascular headaches. Trends Pharmacol. Sci. 15, 149-153.
  295. Ortiz de Montellano, P.R., Nishida, C., Rodriguez­Crespo, I. and Gerber, N. (1998) Nitric oxide synthase structure and electron transfer. Drug Metab. Dispos. 26, 1185-1189.
  296. Osawa, Y., Nakatsuka, K., Williams, M.S., Kindt, J.T. and Nakatsuka, M. (1996) Reactions of reactive metabolites with hemoproteins - Toxicological implications: Covalent alteration of hemoproteins. Adv. Exp. Med. Biol. 387, 37-45.
  297. Oswald, I.P., Wynn, T.A., Sher, A. and James, S.L. (1994) NO as an effector molecule of parasite killing: Modulation of its synthesis by cytokines. Comp. Biochem. Physiol. C 108, 11-18.
  298. Paakkari, I. and Lindsberg, P. (1995) Nitric oxide in the central nervous system. Ann. Med. 27, 369-377.
  299. Palmer, R.M. (1993a) The L­arginine:nitric oxide pathway. Curr. Opin. Nephrol. Hypertens. 2, 122-128.
  300. Palmer, R.M. (1993b) The discovery of nitric oxide in the vessel wall. A unifying concept in the pathogenesis of sepsis. Arch. Surg. 128, 396-401.
  301. Pasternak, G.W., Kolesnikov, Y.A. and Babey, A.M. (1995) Perspectives on the N­methyl­D­aspartate/nitric oxide cascade and opioid tolerance. Neuropsychopharmacology 13, 309-313.
  302. Pastor, C.M. and Billiar, T.R. (1995) Regulation and functions of nitric oxide in the liver in sepsis and inflammation. New Horiz. 3, 65-72.
  303. Pfeilschifter, J., Eberhardt, W., Hummel, R., Kunz, D., Muhl, H., Nitsch, D., Pluss, C. and Walker, G. (1996) Therapeutic strategies for the inhibition of inducible nitric oxide synthase - Potential for a novel class of anti­inflammatory agents. Cell Biol. Int. 20, 51-58.
  304. Pollock, J.S., Förstermann, U., Tracey, W.R. and Nakane, M. (1995) Nitric oxide synthase isozymes antibodies. Histochem. J. 27, 738-744.
  305. Ponting, C.P. and Phillips, C. (1995) DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins. Trends Biochem. Sci. 20, 102-103.
  306. Porsti, I. and Paakkari, I. (1995) Nitric oxide­based possibilities for pharmacotherapy. Ann. Med. 27, 407-420.
  307. Poulos, T.L., Raman, C.S. and Li, H. (1998) NO news is good news. Structure 6,255-258.
  308. Poulos, T.L., Li, H. and Raman, C.S. (1999) Heme­mediated oxygen activation in biology: cytochrome c oxidase and nitric oxide synthase. Curr. Opin. Chem. Biol. 3, 131-137.
  309. Prabhakar, N.R. (1995) Gases as chemical messengers in the carotid body. Role of nitric oxide and carbon monoxide in chemoreception. Adv. Exp. Med. Biol. 393, 309-312.
  310. Prince, R.C. and Gunson, D.E. (1993) Rising interest in nitric oxide synthase. Trends Biochem. Sci. 18, 35-36.
  311. Radomski, M.W. (1995) Nitric oxide: biological mediator, modulator and effector. Ann. Med. 27, 321-329.
  312. Radomski, M.W. and Moncada, S. (1993a) The biological and pharmacological role of nitric oxide in platelet function. Adv. Exp. Med. Biol. 344, 251-264.
  313. Radomski, M.W. and Moncada, S. (1993b) Regulation of vascular homeostasis by nitric oxide. Thromb. Haemost. 70, 36-41.
  314. Ralston, S.H. (1997) Nitric oxide and bone: what a gas! Br. J. Rheumatol. 36, 831-838.
  315. Rand, M.J. and Li, C.G. (1995) Nitric oxide as a neurotransmitter in peripheral nerves: Nature of transmitter and mechanism of transmission. Annu. Rev. Physiol. 57, 659-682.
  316. Reid, I.A. and Chiu, Y.J. (1995) Nitric oxide and the control of renin secretion. Fundam. Clin. Pharmacol. 9, 309-323.
  317. Rettori, V. and McCann, S.M. (1997) The mechanism of action of alcohol to suppress gonadotropin secretion. Mol. Psychiatry 2, 350-354.
  318. Reutov, V.P. and Sorokina, E.G. (1998) NO­synthase and nitrite­reductase components of nitric oxide cycle. Biochemistry (Moscow) 63, 874-884 (English); Biokhimiia (Moscow) 63, 1029 (Russian).
  319. Robbins, R.A. and Grisham, M.B. (1997) Nitric oxide. Int. J. Biochem. Cell. Biol. 29, 857-860.
  320. Robinson, L.J. and Michel, T. (1996) Endothelial nitric oxide synthase expression in heterologous systems. Methods Enzymol. 269, 55-64.
  321. Robinson, L.J., Ghanouni, P. and Michel, T. (1996) Posttranslational modifications of endothelial nitric oxide synthase. Methods Enzymol. 268, 436-448.
  322. Ross, M.E. and Iadecola, C. (1996) Nitric oxide synthase expression in cerebral ischemia: Neurochemical, immunocytochemical, and molecular approaches. Methods Enzymol. 269, 408-426.
  323. Rossaint, R. (1994) Nitric oxide: a new area in intensive care. Presse Med. 23, 855-858.
  324. Sabatini, D.M., Lai, M.M. and Snyder, S.H. (1997) Neural roles of immunophilins and their ligands. Mol. Neurobiol. 15, 223-239.
  325. Salzman, A.L. (1995) Nitric oxide in the gut. New Horiz. 3, 33-45; New Horiz. 3, 352-364.
  326. Samdani, A.F., Dawson, T.M. and Dawson, V.L. (1997) Nitric oxide synthase in models of focal ischemia. Stroke 28, 1283-1288.
  327. Scher, W. and Scher, B.M. (1992) A possible role for nitric oxide in glutamate (MSG)­induced Chinese restaurant syndrome, glutamate­induced asthma, `hot­dog headache', pugilistic Alzheimer's disease, and other disorders. Med. Hypotheses 38, 185-188.
  328. Schiffrin, E.L. (1995) Vascular structure in NG­nitro­L­arginine methyl ester­induced hypertension: Methodological considerations for studies of small arteries in hypertension. J. Hypertens. 13, 817-821.
  329. Schini, V.B. and Vanhoutte, P.M. (1993) Role of the L­arginine-nitric oxide pathway in vascular smooth muscle. Eur. Heart J. Suppl. I, 16-21.
  330. Schini­Kerth, V.B. and Vanhoutte, P.M. (1995) Nitric oxide synthases in vascular cells. Exp. Physiol. 80, 885-905.
  331. Schini, V.B., Busse, R. and Vanhoutte, P.M. (1994a) Inducible nitric oxide synthase in vascular smooth muscle. Arzneimittelforschung 44, 432-435.
  332. Schini, V.B., Busse, R. and Vanhoutte, P.M. (1994b) Inflammatory mediators induce the production of nitric oxide in vascular smooth muscle. Exp. Nephrol. 2, 139-144.
  333. Schmidt, H.H. (1994) NO, endogener Botenstoff und Zellgift. [NO, endogenous messenger and cell poison] Med. Monatsschr. Pharm. 17, 168-185.
  334. Schmidt, H.H., Lohmann, S.M. and Walter, U. (1993) The nitric oxide and cGMP signal transduction system: Regulation and mechanism of action. Biochim. Biophys. Acta 1178, 153-175.
  335. Schmidt, H.H., Pollock, J.S., Nakane, M., Förstermann, U. and Murad, F. (1992) Ca2+/calmodulin­regulated nitric oxide synthases. Cell Calcium 13, 427-434.
  336. Schmidt, H.H., Hofmann, H. and Ogilvie, P. (1995) Regulation and dysregulation of constitutive nitric oxide synthases types I and III. Curr. Top. Microbiol. Immunol. 196, 75-86.
  337. Schulz, J.B., Matthews, R.T. and Beal, M.F. (1995) Role of nitric oxide in neurodegenerative diseases. Curr. Opin. Neurol. 8, 480-486.
  338. Schuman, E.M. and Madison, D.V. (1994) Nitric oxide and synaptic function. Annu. Rev. Neurosci. 17, 153-183.
  339. Semenza, G.L., Agani, F., Booth, G., Forsythe, J., Iyer, N., Jiang, B.H., Leung, S., Roe, R., Wiener, C. and Yu, A. (1997) Structural and functional analysis of hypoxia­inducible factor 1. Kidney Int. 51, 553-555.
  340. Sessa, W.C. (1994) The nitric oxide synthase family of proteins. J. Vasc. Res. 31, 131-143.
  341. Shaul, P.W. (1995) Nitric oxide in the developing lung. Adv. Pediatr. 42, 367-414.
  342. Shaul, P.W. (1997) Ontogeny of nitric oxide in the pulmonary vasculature. Semin. Perinatol. 21, 381-392.
  343. Shen, W., Zhang, X., Zhao, G., Wolin, M.S., Sessa, W. and Hintze, T.H. (1995) Nitric oxide production and NO synthase gene expression contribute to vascular regulation during exercise. Med. Sci. Sports Exerc. 27, 1125-1134.
  344. Sies, H. (1993) Strategies of antioxidant defense. Eur. J. Biochem. 215, 213-219.
  345. Sies, H. and de Groot, H. (1992) Role of reactive oxygen species in cell toxicity. Toxicol. Lett. 64-65, 547-551.
  346. Smith, T.W., Balligand, J.L., Kaye, D.M., Wiviott, S.D., Simmons, W.W., Han, X., Michel, T., Singh, K. and Kelly, R.A. (1996) The role of the NO pathway in the control of cardiac function. J. Card. Fail. 2, S141-S147.
  347. Snyder, S.H. and Bredt, D.S. (1991) Nitric oxide as a neuronal messenger. Trends Pharmacol. Sci. 12, 125-128.
  348. Sooranna, S.R., Morris, N.H. and Steer, P.J. (1995) Placental nitric oxide metabolism. Reprod. Fertil. Dev. 7, 1525-1531.
  349. Southan, G.J. and Szabo, C. (1996) Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem. Pharmacol. 51, 383-394.
  350. Sparrow, J.R. (1994) Inducible nitric oxide synthase in the central nervous system. J. Mol. Neurosci. 5, 219-229.
  351. Stamler, J.S., Singel, D.J. and Loscalzo, J. (1992) Biochemistry of nitric oxide and its redox­activated forms. Science 258, 1898-1902.
  352. Star, R.A. (1993) Am. J. Med. Sci. 306, 348-358.
  353. Star, R.A. (1997) Intrarenal localization of nitric oxide synthase isoforms and soluble guanylyl cyclase. Clin. Exp. Pharmacol. Physiol. 24, 607-610.
  354. Stewart, D.J. (1994) Endothelial dysfunction in pulmonary vascular disorders. Arzneimittelforschung 44, 451-454.
  355. Stoclet, J.­C., Muller, B., Andriantsitohaina, R. and Kleschyov, A. (1998) Overproduction of nitric oxide in pathophysiology of blood vessels. Biochemistry (Moscow) 63, 826-832 (English); Biokhimiia (Moscow) 63, 976-983 (Russian).
  356. Stuehr, D.J. (1996) Purification and properties of nitric oxide synthases. Methods Enzymol. 268, 324-333.
  357. Stuehr, D.J. (1997) Structure-function aspects in the nitric oxide synthases. Annu. Rev. Pharmacol. Toxicol. 37, 339-359.
  358. Stuehr, D.J. and Griffith, O.W. (1992) Mammalian nitric oxide synthases. Adv. Enzymol. Relat. Areas Mol. Biol. 65, 287-346.
  359. Stuehr, D.J., Abu­Soud, H.M., Rousseau, D.L., Feldman, P.L. and Wang, J. (1995) Control of electron transfer in neuronal nitric oxide synthase by calmodulin, substrate, substrate analogs, and nitric oxide. Adv. Pharmacol. 34, 207-213.
  360. Suzuki, H., Menegazzi, M., Carcereri de Prati, A., Mariotto, S. and Armato, U. (1995) Nitric oxide in the liver: physiopathological roles. Adv. Neuroimmunol. 5, 379-410.
  361. Szabo, C. (1995) Alterations in nitric oxide production in various forms of circulatory shock. New Horiz. 3, 2-32.
  362. Szabo, C. (1996) Physiological and pathophysiological roles of nitric oxide in the central nervous system. Brain Res. Bull. 41, 131-141.
  363. Szabo, C. and Thiemermann, C. (1994) Invited opinion: Role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury. Shock 2, 145-155.
  364. Szabo, C. and Thiemermann, C. (1995) Regulation of the expression of the inducible isoform of nitric oxide synthase. Adv. Pharmacol. 34, 113-153.
  365. Taylor, B.S., Alarcon, L.H. and Billiar, T.R. (1998) Inducible nitric oxide synthase in the liver: Regulation and function. Biochemistry (Moscow) 63, 766-781 (English); Biokhimiia (Moscow) 63, 905-923 (Russian).
  366. Thiemermann, C. (1994) The role of the L­arginine:nitric oxide pathway in circulatory shock. Adv. Pharmacol. 28, 45-79.
  367. Thiemermann, C. (1995) Selective inhibition of the activity of inducible nitric oxide synthase in septic shock. Prog. Clin. Biol. Res. 392, 383-392.
  368. Tibballs, J. (1993) The role of nitric oxide (formerly endothelium­derived relaxing factor - EDRF) in vasodilatation and vasodilator therapy. Anaesth. Intensive Care 21, 759-773.
  369. Tikkanen, I. and Fyhrquist, F. (1995) Nitric oxide in hypertension and renal diseases. Ann. Med. 27, 353-357.
  370. Toda, N. (1995) Nitroxidergic nerves and hypertension. Hypertens. Res. 18, 19-26.
  371. Umans, J.G. and Levi, R. (1995) Nitric oxide in the regulation of blood flow and arterial pressure. Annu. Rev. Physiol. 57, 771-790.
  372. Ungureanu­Longrois, D., Balligand, J.L., Kelly, R.A. and Smith, T.W. (1995) Myocardial contractile dysfunction in the systemic inflammatory response syndrome: Role of a cytokine­inducible nitric oxide synthase in cardiac myocytes. J. Mol. Cell Cardiol. 27, 155-167.
  373. Ursell, P.C. and Mayes, M. (1995) Anatomic distribution of nitric oxide synthase in the heart. Int. J. Cardiol. 50, 217-223.
  374. Vallance, P. and Moncada, S. (1993) Role of endogenous nitric oxide in septic shock. New Horiz. 1, 77-86.
  375. Vallance, P. and Moncada, S. (1994) Nitric oxide - from mediator to medicines. J. R. Coll. Physicians Lond. 28, 209-219.
  376. Vanhoutte, P.M. (1992) Inducible nitric oxide synthase and vascular smooth muscle. Jpn. J. Pharmacol. 58 Suppl. 2, 192P-199P.
  377. Vaupel, D.B., Kimes, A.S. and London, E.D. (1995) Nitric oxide synthase inhibitors. Preclinical studies of potential use for treatment of opioid withdrawal. Neuropsychopharmacology 13, 315-322.
  378. Verrecchia, C., Boulu, R.G. and Plotkine, M. (1995) Neuroprotective and deleterious effects of nitric oxide on focal cerebral ischemia­induced neurone death. Adv. Neuroimmunol. 5, 359-378.
  379. Vilcek, J. and Oliveira, I.C. (1994) Recent progress in the elucidation of interferon­gamma actions: Molecular biology and biological functions. Int. Arch. Allergy Immunol. 104, 311-316.
  380. Vincent, S.R. (1994) Nitric oxide: a radical neurotransmitter in the central nervous system. Prog. Neurobiol. 42, 129-160.
  381. Vincent, S.R. and Hope, B.T. (1992) Neurons that say NO. Trends Neurosci. 15, 108-113.
  382. Vodovotz, Y. and Bogdan, C. (1994) Control of nitric oxide synthase expression by transforming growth factor­ß: Implications for homeostasis. Prog. Growth Factor Res. 5, 341-351.
  383. Wang, Y. and Marsden, P.A. (1995a) Nitric oxide synthases: Biochemical and molecular regulation. Curr. Opin. Nephrol. Hypertens. 4, 12-22.
  384. Wang, Y. and Marsden, P.A. (1995b) Nitric oxide synthases: gene structure and regulation. Adv. Pharmacol. 34, 71-90.
  385. Wang, Z.Z., Stensaas, L.J., Bredt, D.S., Dinger, B.G. and Fidone, S.J. (1994) Mechanisms of carotid body inhibition. Adv. Exp. Med. Biol. 360, 229-235.
  386. Weiner, C.P. and Thompson, L.P. (1997) Nitric oxide and pregnancy. Semin. Perinatol. 21, 367-380.
  387. Werner, E.R., Werner­Felmayer, G., Wachter, H. and Wachter, H. (1996a) Biosynthesis of nitric oxide: dependence on pteridine metabolism. Rev. Physiol. Biochem. Pharmacol. 127, 97-135.
  388. Werner, E.R., Werner­Felmayer, G. and Wachter, H. (1996b) High­performance liquid chromatographic methods for the quantification of tetrahydrobiopterin biosynthetic enzymes. J. Chromatogr. B684, 51-58.
  389. Werner­Felmayer, G., Werner, E.R., Fuchs, D., Hausen, A., Reibnegger, G., and Wachter, H. (1991) On multiple forms of NO synthase and their occurrence in human cells. Res. Immunol. 142, 555-561.
  390. Werner­Felmayer, G., Werner, E.R., Weiss, G. and Wachter, H. (1993) Modulation of nitric oxide synthase activity in intact cells by intracellular tetrahydrobiopterin levels. Adv. Exp. Med. Biol. 338, 309-312.
  391. Whittle, B.J. (1995) Nitric oxide in physiology and pathology. Histochem. J. 27, 727-737.
  392. Whittle, B.J., Boughton­Smith, N.K. and Moncada, S. (1992) Biosynthesis and role of the endothelium­derived vasodilator, nitric oxide, in the gastric mucosa. Ann. N. Y. Acad. Sci. 664, 126-139.
  393. Wickelgren, I. (1997) Biologists catch their first detailed look at NO enzyme. Science 278, 389.
  394. Wildhirt, S.M., Dudek, R.R., Suzuki, H. and Bing, R.J. (1995) Involvement of inducible nitric oxide synthase in the inflammatory process of myocardial infarction. Int. J. Cardiol. 50, 253-261.
  395. Wolf, G. (1997) Nitric oxide and nitric oxide synthase: biology, pathology, localization. Histol. Histopathol. 12, 251-261.
  396. Wolfe, T.A. and Dasta, J.F. (1995) Use of nitric oxide synthase inhibitors as a novel treatment for septic shock. Ann. Pharmacother. 29, 36-46.
  397. Wong, G.K. and Garbers, D.L. (1992) Receptor guanylyl cyclases. J. Clin. Invest. 90, 299-305.
  398. Wong, G.K. and Marsden, P.A. (1996) Nitric oxide synthases: regulation in disease. Nephrol. Dial. Transplant. 11, 215-220.
  399. Wong, J.M. and Billiar, T.R. (1995) Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation. Adv. Pharmacol. 34, 155-170.
  400. Wood, P.L. and Rao, T.S. (1991) A review of in vivo modulation of cerebellar cGMP levels by excitatory amino acid receptors: role of NMDA, quisqualate and kainate subtypes. Prog. Neuropsychopharmacol. Biol. Psychiatry 15, 229-235.
  401. Wu, K.K. (1995) Inducible cyclooxygenase and nitric oxide synthase. Adv. Pharmacol. 33, 179-207.
  402. Wu, C.­C. and Thiemermann, C. (1996) Biological control and inhibition of induction of nitric oxide synthase. Methods Enzymol. 268, 408-420.
  403. Wu, G. and Morris, S.M., Jr. (1998) Arginine metabolism: nitric oxide and beyond. Biochem. J. 336, 1-17.
  404. Xia, H. and Bredt, D.S. (1996) Cloned and expressed nitric oxide synthase proteins. Methods Enzymol. 268, 427-436.
  405. Xie, K., Dong, Z. and Fidler, I.J. (1996) Activation of nitric oxide synthase gene for inhibition of cancer metastasis. J. Leukoc. Biol. 59, 797-803.
  406. Youdim, M.B. and Lavie, L. (1994) Selective MAO­A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson's disease. Life Sci. 55, 2077-2082.
  407. Yokoyama, M., Hirata, K., Kawashima, S. and Kawahara, Y. (1996) Regulation of nitric oxide synthase gene expression by cytokines. J. Card. Fail. 2, S179-S185.
  408. Young, A.P., Murad, F., Vaessin, H., Xie, J. and Rife, T.K. (1995) Transcription of the human neuronal nitric oxide synthase gene in the central nervous system is mediated by multiple promoters. Adv. Pharmacol. 34, 91-112.
  409. Yun, H.Y., Dawson, V.L. and Dawson, T.M. (1996) Neurobiology of nitric oxide. Crit. Rev. Neurobiol. 10, 291-316.
  410. Zhang, J. and Steiner, J.P. (1995) Nitric oxide synthase, immunophilins and poly(ADP­ribose) synthetase: Novel targets for the development of neuroprotective drugs. Neurol. Res. 17, 285-288.

Books

  1. Cubberley, R.R. (1996) The cofactor and substrate binding sites of human inducible nitric oxide synthase. Ph.D. Thesis, University of Warwick.
  2. Feelisch, M. and Stamler, J.S., Eds. (1996) Methods in Nitric Oxide Research. Wiley, Chichester.
  3. Lancaster, J., Jr., Ed. (1996) Nitric oxide: Principles and Actions. Academic Press, San Diego.
  4. Maines, M.D., Ed. (1996) Nitric Oxide Synthase: Characterization and Functional Analysis. Academic Press, San Diego.
  5. Moncada, S., Marletta, M.A., Hibbs, J.B., Jr. and Higgs, E.A., Eds. (1992) The Biology of Nitric Oxide, vol. 1: Physiological and Clinical Aspects. Portland Press, London.
  6. Moncada, S., Marletta, M.A., Hibbs, J.B., Jr. and Higgs, E.A., Eds. (1992) The Biology of Nitric Oxide, vol. 2: Enzymology, Biochemistry and Immunology. Portland Press, London.
  7. Moncada, S., Feelisch, M., Busse, R. and Higgs, E.A., Eds. (1994) The Biology of Nitric Oxide, vol. 3: Physiological and Clinical Aspects. Portland Press, London.
  8. Moncada, S., Feelisch, M., Busse, R. and Higgs, E.A., Eds. (1994) The Biology of Nitric Oxide, vol. 4: Enzymology, Biochemistry and Immunology. Portland Press, London.
  9. Moncada, S., Stamler, J., Gross, S. and Higgs, E.A., Eds. (1996) The Biology of Nitric Oxide, vol. 5: Proceedings of the 4th International Meeting on the Biology of Nitric Oxide, Florida, USA. Portland Press, London.
  10. Packer, L., Ed. (1996a) Methods in Enzymology, vol. 268. Nitric Oxide, Part A: Sources and Detection of NO; NO Synthase. Academic Press, San Diego.
  11. Packer, L., Ed. (1996b) Methods in Enzymology, vol. 268. Nitric Oxide, Part B: Physiological and Pathological Processes. Academic Press, San Diego.
  12. Titheradge, M.A., Ed. (1998) Methods in Molecular Biology, vol. 100: Nitric Oxide Protocols. Humana Press, Totowa.
  13. Vanin, A.F., Ed. (1998) Special Issue: Biological Role of Nitric Oxide. Biochemistry (Moscow) vol. 63, no. 7.
  14. Weissman, B.A., Allon, N. and Shapira, S., Eds. (1995) Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide. Plenum Press, New York.

Nobel Prize

  1. Furchgott, R.F., Ignarro, L.J. and Murad, F. The Nobel Prize in Physiology or Medicine 1998 "for their discoveries concerning nitric oxide as a signalling molecule in the cardiovascular system".
Bibliography on structural studies of nitric oxide synthases