Haem proteins

KEGG	PUMA	Boehringer Mannheim map					SoyBase	EcoCyc
MAP00860; Porphyrin and chlorophyll metabolism	Heme and porphyrins	H5	I5	J5	K5	L5	Heme synthesis	Biosynthesis of proto and siroheme
		H6	I6	J6	K6	L6
		H7

Function	Protein class / family
Catalysis Haem, haem-thiolate, and sirohaem enzymes in ENZYME database Haem enzymes in LIGAND database	Oxidoreductases Catalases Haem-thiolate Peroxidases
Electron transfer	Cytochromes
Oxygen transport and storage	Globins
Nitric oxide transport	Nitrophorin

Haem iron coordination	Axial iron ligands	Protein class
Hexacoordinate	N_His; N_His	Cytochrome c oxidase haem a (`cyt a') Cytochrome b/b₆ Cytochrome b₅ Cytochromes c (Class III and IV) Cytochrome c₅₅₄ (haems 3 and 4) Cytochrome cd₁ nitrite reductase (cdomain) Hydroxylamine oxidoreductase (haems c)
Hexacoordinate	N_His; N_His	Cytochrome c₅₅₄ (haem 1)
Hexacoordinate	N_His; S_Met	Soluble cytochrome b₅₆₂ Cytochromes c (cyt c₁, Class I, IIb, and IV)
Hexacoordinate	N_His; N_Tyr	Cytochrome f
Hexacoordinate	N_His; O_Tyr	Cytochrome cd₁ nitrite reductase (d₁domain)
Hexacoordinate	S_Met; S_Met	Bacterioferritin (cyt b₁; cyt b₅₅₇)
Pentacoordinate / Hexacoordinate	N_His; (O₂, CO, ·NO, CN¯ or other ligand)	Cytochrome c oxidase haem a₃ (`cyt a₃') Cytochrome c₅₅₄ (haem 2) Cytochrome c' Globins Guanylate cyclase (soluble) Hydroxylamine oxidoreductase (haem P460) Nitrophorins Peroxidases
Pentacoordinate / Hexacoordinate	O_Tyr; (H₂O₂, O₂ or other ligand)	Catalases
Pentacoordinate / Hexacoordinate	S_Cys; (O₂, CO, ·NO or other ligand)	Haem-thiolate Haem chloroperoxidase Nitric oxide synthases P450 proteins
Pentacoordinate / Hexacoordinate	S_Cys; (NO₂¯, SO₃¯ or other ligand)	Sirohaem-Fe₄S₄ enzymes

Haem type / LIGAND entry	Protein class
Chlorocruorohaem	Globins (chlorocruorins)
Haem a	Cytochrome c oxidase
Haem b (C00032)	Catalases Cytochromes b Globins Guanylate cyclase (soluble) Haem-thiolate Nitrophorins Peroxidases
Haem c	Cytochromes c Hydroxylamine oxidoreductase
Haem d	Catalases Cytochromes d
Haem d₁	Cytochrome cd₁ nitrite reductase (d₁domain)
Haem o	Cytochrome o oxidase
Haem P460	Hydroxylamine oxidoreductase
Sirohaem (C00748)	Sirohaem-Fe₄S₄ enzymes

PRINTS ID	PRINTS AC	PROSITE/BLOCKS ID	PROSITE AC	BLOCKS AC
Oxidoreductases
Catalases
CATALASE	PR00067	CATALASE_1 CATALASE_2	PS00437 PS00438	BL00437
Cytochrome oxidases
-	-	COX1	PS00077	BL00077
Haem-thiolate
-	-	CYS_SYNTHASE	PS00901	BL00901
BP450	PR00359	CYTOCHROME_P450	PS00086	BL00086
EP450I	PR00463
EP450II	PR00464
EP450IV	PR00465
MITP450	PR00408
P450	PR00385
Peroxidases
ANPEROXIDASE	PR00457	PEROXIDASE_1 PEROXIDASE_2	PS00435 PS00436	BL00435
ASPEROXIDASE	PR00459
BPEROXIDASE	PR00460
LIGNINASE	PR00462
PEROXIDASE	PR00458
PLPEROXIDASE	PR00461
Sirohaem-Fe₄S₄ enzymes
SIROHAEM	PR00397	NIR_SIR	PS00365	BL00365
Cytochromes
Cytochromes b
BACFERRITIN	PR00601	BACTERIOFERRITIN	PS00549	BL00549
-	-	CYTOCHROME_B_HEME CYTOCHROME_B_QO	PS00192 PS00193	BL00192
CYTOCHROMEB5	PR00363	CYTOCHROME_B5	PS00191	BL00191
-	-	CYTOCHROME_B559	PS00537	BL00537
NIHGNASECYTB	PR00161	NI_HGENASE_CYTB_1 NI_HGENASE_CYTB_2	PS00882 PS00883	BL00882
-	-	SDH_CYT_1 SDH_CYT_2	PS01000 PS01001	BL01000
Cytochromes c
CYTOCHROMEC1	PR00603	CYTOCHROME_C	PS00190	BL00190
CYTCHRMECIAB	PR00604
CYTCHROMECIC	PR00605
CYTCHROMECID	PR00606
CYTCHROMECIE	PR00607
CYTCHROMECII	PR00608
CYTOCHROMEC3	PR00609
CYTOCHROMEF	PR00610
Globins
ERYTHCRUORIN	PR00611	GLOBIN	PS01033	BL01033
HAEMOGLOBIN	PR00612
MYOGLOBIN	PR00613
PLANTGLOBIN	PR00188	PLANT_GLOBIN	PS00208	BL00208

PROMISE ID	Description
ANPEROXIDASE	Animal haem peroxidases (myeloperoxidase, eosinophil peroxidase, lactoperoxidase, thyroid peroxidase, prostaglandin H synthase, peroxidasin)
BACFERRITIN	Bacterioferritin (aka cytochrome b₁ and cytochrome b₅₅₇)
CATALASE	Catalases
COX	Cytochrome c oxidase
CYTB5	Cytochrome b₅ family
CYTB562	Soluble cytochrome b₅₆₂
CYTBHBL	Cytochrome b/b₆ (b_Hb_L)
CYTC1	Cytochrome c₁
CYTC554	Tetrahaem cytochrome c₅₅₄ from Nitrosomonas europaea
CYTCD1	Cytochrome cd₁ nitrite reductase (cytochrome oxidase)
CYTCI	Class I cytochromes c (mitochondrial cyt c, cyt c₂, cyt c₄, cyt c₅, cyt c554, cyt c₆, cyt c₈)
CYTCII	Class II cytochromes c (cyt c', cyt c556)
CYTCIII	Class III cytochromes c (bacterial multihaem cytochromes: cyt c₃, cyt c₇, HMC)
CYTCIV	Class IV cytochromes c (photosynthetic reaction centre cyt c subunit)
CYTF	Cytochrome f
FPBPEROXIDASE	Fungal, plant and bacterial haem peroxidases (yeast cytochrome c peroxidase, ascorbate peroxidase, bacterial catalaseperoxidases, lignin peroxidase, manganese peroxidase, secretory plant peroxidases)
GLOBINS	Globins
HAEMCPO	Haem chloroperoxidase
HAO	Hydroxylamine oxidoreductase
NITROPHORIN	Nitrophorins
NOS	Nitric oxide synthases
P450	P450 proteins
SIROHAEM	Sirohaem-Fe₄S₄ enzymes (including sulphite reductases and assimilatory nitrite reductases)

HET group	Description	Formula
CLN	Sulphursubstituted protoporphyrin IX	C₃₄H₃₀N₄O₄SFe^2+/3+
COH	Cobaltsubstituted protoporphyrin IX	C₃₄H₃₂N₄O₄Co²⁺
DHE	Haem d₁	C₃₄H₃₂N₄O₁₀Fe^2+/3+
HE6	6,7Dicarboxylhaemin	C₂₈H₂₄N₄O₄Fe^2+/3+
HEA	Haem a	C₄₉H₆₂N₄O₆Fe^2+/3+
HEC	Haem c	C₃₄H₃₄N₄O₄Fe^2+/3+
HEM	Iron·protoporphyrin IX	C₃₄H₃₂N₄O₄Fe^2+/3+
PP9	Protoporphyrin IX	C₃₄H₃₄N₄O₄
POR	Iron(III)·porphyrin	C₂₀H₁₂N₄Fe³⁺
SRM	Sirohaem	C₄₂H₄₂N₄O₁₆Fe^2+/3+

Haem type	Protein class / family
Haem a	Cytochrome c oxidase
Haem b	Catalases Cytochromes b Bacterioferritin (cytochrome b₁) Cytochrome b/b₆ Cytochrome b₅ family Soluble cytochrome b₅₆₂ Globins Haem-thiolate Haem chloroperoxidase Nitric oxide synthase P450 proteins Nitrophorins Peroxidases Animal peroxidases Fungal and plant peroxidases
Haem c	Class I cytochromes c Class II cytochromes c Class III cytochromes c Class IV cytochromes c Cytochrome c₁ Cytochrome cd₁ nitrite reductase Cytochrome f
Sirohaem	Sirohaem-Fe₄S₄ enzymes