Cytochrome c oxidase structure [1]

PDB	scop	BSM	RELI Base	Header	¹
1occ	1occ	1occ	1occ	Cytochrome c oxidase (fully oxidised) (dimer) (complex with Mg2+ and Zn2+); bovine	MS7MB2

a

b

c

d

e

f

¹ Macromolecular Structures abstract. Full text is available to BioMedNet Members

1. Ribbon representation of subunits I (orange), II (pink) and III (yellow) of the bovine cytochrome c oxidase (PDB code 1OCC, chains A, B and C, respectively).
2. Haem groups, copper (green) and magnesium (cyan) ions and some of their ligand residues. Cu_B copper is situated in front of the haem a₃ plane. His_A­240, His_A­290 and His_A­291 (Cu_B ligands), Met_B­207 (a Cu_A ligand) and His_A­376 (haem a₃ axial ligand) are not shown. Note that for Glu_B­198, backbone N and O atoms are also shown (the backbone carbonyl oxygen is a ligand of a copper atom in the Cu_A centre).
3. As a, rotated 70° around y axis.
4. As b, rotated 70° around y axis. His_A­61 and His_A­378 (haem a axial ligands) are not shown.
5. Ribbon representation of the subunit I of cytochrome c oxidase along the membrane normal (from the cytosolic side). Helices I, II, XI and XII (orange), VII, VIII, IX and X (violet), and III, IV, V and VI (crimson) form three semicircles, one of which (orange) envelopes haem a and the other (violet) envelopes the a₃-Cu_B center.
6. Haem groups, Cu_B and their ligand residues only (orientation as e).

1. Tsukihara, T., Aoyama, H., Yamashita, E., Tomizaki, T., Yamaguchi, H., Shinzawa­Itoh, K., Nakashima, R., Yaono, R. and Yoshikawa, S. (1996) The whole structure of the 13­subunit oxidized cytochrome c oxidase at 2.8 Å. Science 272, 1136-1144.
2. Kraulis, P.J. (1991) MOLSCRIPT: a program to produce both detailed and schematic plots of protein structure. J. Appl. Crystallogr. 24, 946-950.

Bibliography on structural studies of cytochrome c oxidases