Created: 14 November 1997
Last modified: 12 October 1998

Molybdopterincontaining proteins

Biosynthesis of molybdopterin in metabolic pathway databases
Molybdopterincontaining proteins by function
Molybdopterincontaining proteins by molybdopterin centre type
Molybdopterincontaining proteins by type and number of prosthetic centres
Molybdopterincontaining proteins in motif databases
Molybdopterincontaining proteins in PROMISE
HET groups in PDB
Molybdopterincontaining proteins in 3D databases
References

All mononuclear molybdenum (Mo) and tungsten (W) proteins possess a pterin cofactor that coordinates to the metal atom via its dithiolene group. The pterin cofactor common to Mo and Wcontaining enzymes is frequently referred to by the trivial name molybdopterin, but this term refers to the metalfree organic cofactor alone [1, 2]. For historical reasons, there are inconsistencies in the terminology used to designate the metalbound molybdopterin [3]; we use the term molybdenum cofactor (Moco) for both Mo and Wbound molybdopterin. In eukaryotic enzymes the molybdopterin exists in the mononucleotide form (R = H), whereas in enzymes from prokaryota it can be found as the dinucleotide of adenine, cytosine, guanine or hypoxanthine (R = AMP, CMP, GMP or HMP).

Molybdopterincontaining proteins can be classified according to their biological function, by molybdopterin centre type, by type and number of prosthetic centres, and by sequence similarity.

Biosynthesis of molybdopterin in metabolic pathway databases

KEGG	PUMA	Boehringer Mannheim map		EcoCyc
MAP00790; Folate biosynthesis	-	K1	L1	Folic acid biosynthesis
MAP00790; Folate biosynthesis	-	K2	L2	Folic acid biosynthesis

Molybdopterincontaining proteins by function

Function	Protein class
Catalysis Molybdenum, tungsten and selenium enzymes in ENZYME database Molybdopterin, molybdenum, tungsten and selenium enzymes in LIGAND database	Oxidoreductases Aldehyde ferredoxin oxidoreductase Aldehyde oxidase Arsenite oxidase Carboxylic acid reductase CO dehydrogenase DMSO reductase Formaldehyde ferredoxin oxidoreductase Formate dehydrogenase Formylmethanofuran dehydrogenase Glyceraldehyde3phosphate ferredoxin oxidoreductase Nitrate reductases Polysulphide reductase Sulphite oxidase Trimethylamine Noxide reductase Xanthine oxidase Xanthine dehydrogenase

Function

Protein class

Catalysis

Molybdenum, tungsten and selenium enzymes in ENZYME database
Molybdopterin, molybdenum, tungsten and selenium enzymes in LIGAND database

Oxidoreductases

Aldehyde ferredoxin oxidoreductase
Aldehyde oxidase
Arsenite oxidase
Carboxylic acid reductase
CO dehydrogenase
DMSO reductase
Formaldehyde ferredoxin oxidoreductase
Formate dehydrogenase
Formylmethanofuran dehydrogenase
Glyceraldehyde3phosphate ferredoxin oxidoreductase
Nitrate reductases
Polysulphide reductase
Sulphite oxidase
Trimethylamine Noxide reductase
Xanthine oxidase
Xanthine dehydrogenase

Molybdopterincontaining proteins by molybdopterin centre type

Molybdopterin centre	Protein family
M·molybdopterin cofactor (M = Mo or W; R = H or CMP)	Sulphite oxidase family Xanthine oxidase family
M·2 molybdopterin (M = Mo or W; R = H, AMP, GMP, HMP)	Aldehyde ferredoxin oxidoreductase family DMSO reductase family

Molybdopterincontaining proteins by type and number of prosthetic centres

Molybdopterincontaining proteins
Simple	Complex
DMSO reductase	Moco-Fe-Sproteins Aldehyde ferredoxin oxidoreductase family DMSO reductase family Xanthine oxidase family Moco-Fe-S-flavoproteins Xanthine oxidase family Moco-haemo-(flavo)proteins Sulphite oxidase family

Molybdopterincontaining proteins in motif databases

PRINTS ID	PRINTS AC	PROSITE/BLOCKS ID	PROSITE AC	BLOCKS AC
EUMOPTERIN	PR00407	MOLYBDOPTERIN_EUK	PS00559	BL00559
-	-	MOLYBDOPTERIN_PROK_1 MOLYBDOPTERIN_PROK_2 MOLYBDOPTERIN_PROK_3	PS00551 PS00490 PS00932	BL00551

Molybdopterincontaining proteins in PROMISE

PROMISE ID	Description
AOR	Aldehyde ferredoxin oxidoreductase family (including aldehyde ferredoxin oxidoreductase, formaldehyde ferredoxin oxidoreductase, glyceraldehyde3phosphate ferredoxin oxidoreductase, carboxylic acid reductase and hydroxycarboxylate viologen oxidoreductase)
SULFOXIDASE	Sulphite oxidase family (including sulphite oxidase and plant and fungal assimilatory nitrate reductases)
DMSOR	DMSO reductase family (including DMSO reductase, dissimilatory nitrate reductases, formylmethanofuran dehydrogenase, trimethylamine Noxide reductase, arsenite oxidase, formate dehydrogenase and polysulphide reductase)
XANTOXIDASE	Xanthine oxidase family (including xanthine oxidase, xanthine dehydrogenase, aldehyde oxidase, CO dehydrogenase)

HET groups in PDB (at BSM)

HET group	Description	Formula	HET group	Description	Formula
4MO	Molybdenum(IV) ion	Mo⁴⁺	6MO	Molybdenum(VI) ion	Mo⁶⁺
MO	Molybdenum ion	Mo^4+/6+
MCN	Molybdopterin cytosine dinucleotide	C₁₉H₂₂N₈O₁₃P₂S₂	MGD	Molybdopterin guanine dinucleotide	C₂₀H₂₄N₁₀O₁₃P₂S₂
MTE	Molybdopterin	C₁₀H₁₄N₅O₆PS₂	PTE	Tungstopterin cofactor	C₂₀H₂₉N₁₀O₁₄MgP₂S₄W

Molybdopterincontaining proteins in 3D databases

Prosthetic centre	Enzymes
Moco	DMSO reductase
Moco-Fe₂S₂	Xanthine oxidase family
Moco-Fe₄S₄/Fe₃S₄	Aldehyde ferredoxin oxidoreductase DMSO reductase family
Moco-haem	Sulphite oxidase family