Bibliography on structural studies of isopenicillin N synthase

1. Chen, V.J., Orville, A.M., Harpel, M.R., Frolik, C.A., Surerus, K.K., Münck, E. and Lipscomb, J.D. (1989) Spectroscopic studies of isopenicillin N synthase. A mononuclear nonheme Fe²⁺ oxidase with metal coordination sites for small molecules and substrate. J. Biol. Chem. 264, 21677-21681.
2. Durairaj, M., Leskiw, B.K. and Jensen, S.E. (1996) Genetic and biochemical analysis of the cysteinyl residues of isopenicillin N synthase from Streptomyces clavuligerus. Can. J. Microbiol. 42, 870-875.
3. Fujishima, Y., Nordlund, P., Pelosi, G., Schofield, C.J., Cole, S.J., Baldwin, J.E. and Hajdu, J. (1994) Crystallization and preliminary X­ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium. J. Mol. Biol. 242, 712-714.
4. Jiang, F., Peisach, J., Ming, L.J., Que, L., Jr. and Chen, V.J. (1991) Electron spin echo envelope modulation studies of the Cu(II)­substituted derivative of isopenicillin N synthase: a structural and spectroscopic model. Biochemistry 30, 11437-11445.
5. Ming, L.J., Que, L., Jr., Kriauciunas, A., Frolik, C.A. and Chen, V.J. (1991) NMR studies of the active site of isopenicillin N synthase, a non­heme iron(II) enzyme. Biochemistry 30, 11653-11659.
6. Orville, A.M., Chen, V.J., Kriauciunas, A., Harpel, M.R., Fox, B.G., Münck, E. and Lipscomb, J.D. (1992) Thiolate ligation of the active site Fe²⁺ of isopenicillin N synthase derives from substrate rather than endogenous cysteine: Spectroscopic studies of site­specific CysSer mutated enzymes. Biochemistry 31, 4602-4612.
7. Randall, C.R., Zang, Y., True, A.E., Que, L., Jr., Charnock, J.M., Garner, C.D., Fujishima, Y., Schofield, C.J. and Baldwin, J.E. (1993) X­ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes. Biochemistry 32, 6664-6673.
8. Roach, P.L., Schofield, C.J., Baldwin, J.E., Clifton, I.J. and Hajdu, J. (1995a) Crystallization and preliminary X­ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans. Protein Science 4, 1007-1009.
9. Roach, P.L., Clifton, I.J., Fülöp, V., Harlos, K., Barton, G.J., Hajdu, J., Andersson, I., Schofield, C.J. and Baldwin, J.E. (1995b) Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes. Nature 375, 700-704.
10. Roach, P.L., Clifton, I.J., Hensgens, C.M.H., Shibata, N., Long, A.J., Strange, R.W., Hasnain, S.S., Schofield, C.J., Baldwin, J.E. and Hajdu, J. (1996) Anaerobic crystallisation of an isopenicillin N synthase·Fe(II)·substrate complex demonstrated by X­ray studies. Eur. J. Biochem. 242, 736-740.
11. Roach, P.L., Clifton, I.J., Hensgens, C.M.H., Shibata, N., Schofield, C.J., Hajdu, J. and Baldwin, J.E. (1997) Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation. Nature 387, 827-830.
12. Sami, M., Brown, T.J., Roach, P.L. and Baldwin, J.E. (1997) Glutamine­330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans. FEBS Lett. 405, 191-194.
13. Scott, R.A., Wang, S., Eidsness, M.K., Kriauciunas, A., Frolik, C.A. and Chen, V.J. (1992) X­ray absorption spectroscopic studies of the high­spin iron(II) active site of isopenicillin N synthase: Evidence for Fe-S interaction in the enzyme­substrate complex. Biochemistry 31, 4596-4601.
14. Valegard, K., van Scheltinga, A.C., Lloyd, M.D., Hara, T., Ramaswamy, S., Perrakis, A., Thompson, A., Lee, H.J., Baldwin, J.E., Schofield, C.J., Hajdu, J. and Andersson, I. 91998) Structure of a cephalosporin synthase. Nature 394, 805-809.

Reviews on isopenicillin N synthase