• Iron-sulphur proteins by function
• Iron-sulphur proteins by Fe-S centre type
• Iron-sulphur proteins by type and number of prosthetic centres
• Iron-sulphur proteins in motif databases
• Iron-sulphur proteins in PROMISE
• HET groups in PDB
• Iron-sulphur proteins in 3­D databases
• References

Iron-sulphur proteins by function

Function	Protein class / family
Catalysis Iron, iron-sulphur and non­haem iron enzymes in ENZYME database Iron and Sulphur enzymes in LIGAND database	Oxidoreductases Bacterial nitrate reductase Formate dehydrogenase Fumarate reductase Glutamine PRPP amidotransferase Hydrogenase Methane monooxygenase NADH:ubiquinone reductase Phthalate dioxygenase reductase Succinate dehydrogenase Sulphite reductase Xanthine dehydrogenase Hydro­lyases Aconitase
Electron transfer	Ferredoxins Rieske proteins Rubredoxins

Iron-sulphur proteins by Fe-S centre type

Iron-sulphur centre	Protein class / family
Fe(SCys)4	Fe(Cys)4 proteins Desulforedoxin­type proteins Desulfoferrodoxin (centre I) Rubredoxin­type proteins Rubrerythrin (centre II)
[Fe2S2](SCys)4	Fe2S2 proteins Adrenodoxin­type ferredoxins Iron hydrogenases Plant­type ferredoxins Xanthine oxidase family
[Fe2S2](SCys)2(NHis)2	Fe2S2 Rieske proteins
[Fe4S4](SCys)4	Fe4S4 proteins Aldehyde ferredoxin oxidoreductase Bacterial­type ferredoxins DMSO reductase family Endonuclease III Iron hydrogenases HiPIPs Mo­nitrogenase component II Nickel-iron hydrogenase `Prismane' proteins (cluster I) Sirohaem-Fe4S4 enzymes Trimethylamine dehydrogenase
[Fe4S4](SCys)3NHis	Nickel-iron hydrogenase
[Fe4S4](SCys)3NHis	Iron hydrogenases
[Fe4S4](SCys)3OAsp	Bacterial­type ferredoxins
[Fe4S4](SCys)3(H2O)n	Aconitase family
[Fe3S4](SCys)3	Fe3S4 proteins Aconitases Bacterial­type ferredoxins Nickel-iron hydrogenase
[Fe8S7](SCys)6NCysOSer	Mo­nitrogenase component I
[Fe8S7](SCys)6
[Fe4S3O2X](SCys)4(OGlu)2NHis	`Prismane' proteins (cluster II)
Some `extinct species' of iron-sulphur clusters (now shown to be erroneous)
[Fe3S3](SCys)5OGlu	Fe3S3 iron-sulphur proteins - see Bacterial­type ferredoxins Erroneous modelling of the [Fe3S4] cluster
[Fe8S8](SCys)6OSer	Mo­nitrogenase component I [Fe8S8] model for P­cluster was incorrectly proposed after modelling a single structure to a superposition of electron densities from a mixture of the two types of [Fe8S7] clusters
[Fe6S6](L)6 (L=ligand)	Fe6S6 proteins - see `Prismane' proteins Proposed on the basis of the similarity of the EPR spectra to those of the synthetic compounds with [Fe6S6] core

Iron-sulphur proteins by type and number of prosthetic centres

Iron-sulphur proteins
Simple	Complex
Rubredoxins Monocentre Dicentre Desulforedoxin Ferredoxins 2Fe Monocluster Dicluster 4Fe Monocluster Dicluster Polycluster Rieske proteins Enzymes Aconitases Endonuclease III Glutamine PRPP amidotransferase Mo­nitrogenase component II (Fe protein)	Iron hydrogenases `Prismane' proteins Rubrerythrin Desulfoferrodoxin Fe-S-flavoproteins Trimethylamine dehydrogenase Fe-S-haemoproteins Sirohaem-Fe4S4 enzymes Fe-S-haemo-flavoproteins Fe-S-Mo­ or Fe-S-W­proteins Aldehyde ferredoxin oxidoreductase family DMSO reductase family Mo­nitrogenase component I (MoFe protein) Xanthine oxidase family Fe-S-mononuclear Fe proteins Aromatic­ring­hydroxylating dioxygenases Fe-S-Ni­proteins Nickel-iron hydrogenase

Iron-sulphur proteins in motif databases

PRINTS ID	PRINTS AC	PROSITE/BLOCKS ID	PROSITE AC	BLOCKS AC
2FE2SFRDOXIN	PR00159	2FE2S_FERREDOXIN	PS00197	BL00197
3FE4SFRDOXIN	PR00352	-	-	-
4FE4SFRDOXIN	PR00353	4FE4S_FERREDOXIN	PS00198	BL00198
7FE8SFRDOXIN	PR00354
ACONITASE	PR00415	ACONITASE	PS00450	BL00450
ADRENODOXIN	PR00355	ADX	PS00814	BL00814
-	-	ENDONUCLEASE_III_1 ENDONUCLEASE_III_2	PS00764 PS01155	BL00764
-	-	GATASE_TYPE_II	PS00443	BL00443
HIPIPFRDOXIN	PR00374	HIPIP	PS00596	BL00596
NIHGNASESMLL	PR00614	-	-	-
-	-	NITROGENASE_1_1 NITROGENASE_1_2	PS00699 PS00090	BL00699
NITROGNASEII	PR00091	NIFH_FRXC_1 NIFH_FRXC_2	PS00746 PS00692	BL00746
-	-	PUR_PYR_PR_TRANSFER	PS00103	BL00103
RIESKE	PR00162	RIESKE_1 RIESKE_2	PS00199 PS00200	BL00199
RNGDIOXGNASE	PR00090	RING_HYDROXYL_ALPHA	PS00570	BL00570
RUBREDOXIN	PR00163	RUBREDOXIN	PS00202	BL00202
SIROHAEM	PR00397	NIR_SIR	PS00365	BL00365

See also a table of Fe-S proteins in PROMISE

PROMISE ID	Description
ACONITASE	Aconitases, iron­responsive element binding proteins (IRE­BP), and ­isopropylmalate isomerases
ADRENODOXIN	Adrenodoxin­type ferredoxins (including adrenodoxin, putidaredoxin and terpredoxin)
ARHD	Aromatic­ring­hydroxylating dioxygenases
AOR	Aldehyde ferredoxin oxidoreductase family
BACFRDX	Bacterial­type mono­, di­ and polycluster ferredoxins
DESULFOREDOXIN	Desulforedoxin­type Fe(Cys)4 proteins
DFX	Desulfoferrodoxin
DMSOR	DMSO reductase family
ENDONUCLEASE3	Endonuclease III
FEHASE	Iron hydrogenases
GPATASE	Glutamine PRPP amidotransferase
HIPIP	High potential iron-sulphur proteins
NIFE	Nickel-iron hydrogenase
NITROGENASE1	Mo­nitrogenase component I (MoFe protein)
NITROGENASE2	Mo­nitrogenase component II (Fe protein)
PLANTFRDX	Plant­type ferredoxins
PRISMANE	`Prismane' proteins
RIESKE	Rieske iron-sulphur proteins
RUBREDOXIN	Rubredoxin­type Fe(Cys)4 proteins
RUBRERYTHRIN	Rubrerythrin
SIROHAEM	Sirohaem-Fe4S4 enzymes (including sulphite reductases and assimilatory nitrite reductases)
TMADH	Trimethylamine dehydrogenase
XANTOXIDASE	Xanthine oxidase family (including xanthine oxidase, xanthine dehydrogenase, aldehyde oxidase, CO dehydrogenase)

HET groups in PDB (at BSM)

^* The [Fe₈S₈] cluster model appears to be wrong.

Iron-sulphur proteins in 3­D databases

Fe-S centre	Electron­transfer proteins	Enzymes
Fe(Cys)4	Desulforedoxin Rubredoxins Rubrerythrin	-
Fe2S2	Adrenodoxin­type ferredoxins Plant­type ferredoxins Rieske iron-sulphur proteins	Xanthine oxidase family
Fe4S4 / Fe3S4	Bacterial­type ferredoxins HiPIPs	Aconitases Aldehyde ferredoxin oxidoreductase DMSO reductase family Endonuclease III Iron hydrogenases Glutamine PRPP amidotransferase Mo­nitrogenase component I Mo­nitrogenase component II Nickel-iron hydrogenase Trimethylamine dehydrogenase

References

1. Bertini, I., Ciurli, S. and Luchinat, C. (1995) The electronic structure of FeS centers in proteins and models. A contribution to the understanding of their electron transfer properties. Structure and Bonding 83, 1-53.
2. Cowan, J.A. (1993) Inorganic Biochemistry: An Introduction. VCH Publishers, New York.
3. IUPAC-IUB commission on biochemical nomenclature (CBN) (1973) Nomenclature of iron-sulfur proteins. 1973 recommendations. Eur. J. Biochem. 35, 1-2.
4. Nomenclature Committee of the International Union of Biochemistry (NC-IUB) (1979) Nomenclature of iron-sulfur proteins. Recommendations 1978. Eur. J. Biochem. 93, 427-430.
5. Nomenclature Committee of the International Union of Biochemistry (NC-IUB) (1991) Nomenclature of electron­transfer proteins. Recommendations 1989. Eur. J. Biochem. 200, 599-611.

General references on iron-sulphur proteins