• Prosthetic group features
• Fe(Cys)₄ proteins in PROMISE
• Fe(Cys)₄ proteins in enzyme databases
• Fe(Cys)₄ proteins in motif databases
• HET groups in PDB
• References

The simplest iron-sulphur centre is the rubredoxin­type [Fe(Cys)₄] mononuclear iron centre, in which iron is tetrahedrally coordinated with four cysteines [1, 2]. Desulforedoxin represents another class of Fe(Cys)₄ proteins with a distorted tetrahedral coordination of the iron [3]. Rubrerythrin and desulfoferrodoxin are fusion proteins containing rubredoxin­type and desulforedoxin­type domains, respectively [4].

Fe(Cys)₄ proteins in PROMISE

PROMISE ID	Description
DESULFOREDOXIN	Desulforedoxin­type Fe(Cys)4 proteins
DFX	Desulfoferrodoxin
RUBREDOXIN	Rubredoxin­type Fe(Cys)4 proteins
RUBRERYTHRIN	Rubrerythrin

Fe(Cys)₄ proteins in enzyme databases

Enzyme cofactors		LIGAND electron transport proteins
ENZYME	LIGAND	Code	Description
Iron	Iron	C00340	Reduced rubredoxin
		C00435	Oxidized rubredoxin
		C02870	Oxidized rubredoxin

Fe(Cys)₄ proteins in motif databases

PRINTS ID	PRINTS AC	PROSITE/BLOCKS ID	PROSITE AC	BLOCKS AC
RUBREDOXIN	PR00163	RUBREDOXIN	PS00202	BL00202

HET groups in PDB (at BSM)

References

1. Bertini, I., Ciurli, S. and Luchinat, C. (1995) The electronic structure of FeS centers in proteins and models. A contribution to the understanding of their electron transfer properties. Structure and Bonding 83, 1-53.
2. Cowan, J.A. (1993) Inorganic Biochemistry: An Introduction. VCH Publishers, New York.
3. Archer, M., Huber, R., Tavares, P., Moura, I., Moura, J.J.G., Carrondo, M.A., Sieker, L.C., LeGall, J. and Romão, M.J. (1995) Crystal structure of desulforedoxin from Desulfovibrio gigas determined at 1.8 Å resolution: a novel non­heme iron protein structure. J. Mol. Biol. 251, 690-702.
4. Moura, I., Tavares, P. and Ravi, N. (1994) Characterization of three proteins containing multiple iron sites: rubrerythrin, desulfoferrodoxin, and a protein containing a six­iron cluster. Methods Enzymol. 243, 216-240.