Aconitase structure [1-3]

PDB	scop	BSM	RELI Base	Header	¹
5acn	5acn	5acn	5acn	Aconitase (inactive [Fe3S4] cluster form) (complex with sulphate and tricarballylic acid); pig heart	-
6acn	6acn	6acn	6acn	Aconitase (activated [Fe4S4] cluster form) (complex with sulphate and tricarballylic acid); pig heart	-
7acn	7acn	7acn	7acn	Aconitase (complex with isocitrate); pig heart	MMS93002

a	b
	c
	d

¹ Macromolecular Structures abstract. Full text is available to BioMedNet Members

1. Ribbon representation of aconitase structure (PDB code 7ACN) [1]. Domain colour­codes: domain I (2-199) = green; domain II (201-315) = blue; domain III (320-488) = cyan; domain IV = (552-754) = violet.
2. [Fe₄S₄] cluster, its Cys ligands and bound isocitrate (orientation as a).
3. Aconitase (PDB code 6ACN) [2]: [Fe₄S₄] cluster, its Cys ligands and bound water (O atom only).
4. Aconitase (PDB code 5ACN) [2, 3]: [Fe₃S₄] cluster and its Cys ligands.

1. Lauble, H., Kennedy, M.C., Beinert, H. and Stout, C.D. (1992) Crystal structures of aconitase with isocitrate and nitroisocitrate bound. Biochemistry 31, 2735-2748.
2. Robbins, A.H. and Stout, C.D. (1989) Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal. Proc. Natl. Acad. Sci. USA 86, 3639-3643.
3. Robbins, A.H. and Stout, C.D. (1985) Iron-sulfur cluster in aconitase. Crystallographic evidence for a three­iron center. J. Biol. Chem. 260, 2328-2333.
4. Kraulis, P.J. (1991) MOLSCRIPT: a program to produce both detailed and schematic plots of protein structure. J. Appl. Crystallogr. 24, 946-950.

Bibliography on structural studies of aconitase